Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:596
Official Symbol:BCL2
Other Aliases:Bcl-2
See related:HGNC:990|MIM:151430|HPRD:01045
Chromosome:18
Location:18q21.33|18q21.3
Gene Description:B-cell CLL/lymphoma 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0044
ORGANISM:human
Entrez Gene ID:596
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:10534122
Addiction Drug:OPIOIDS
Addiction Drug Detail:HEROIN ABUSE
Addiction Brain Area:Jurkat cells / T lymphocytes
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12043CBCerebellum3.010103464126593.56821203231812
12043CTXCerebral cortex5.837308406829834.31053590774536
12043HIPHippocampal region2.192726135253911.84642577171326
12043HPFHippocampal formation2.086574554443361.60668802261353
12043HYHypothalamus3.118517398834232.31255173683167
12043LSXLateral septal complex0.9855632781982420.698410332202911
12043MBMidbrain6.038042068481455.37382650375366
12043MYMedulla11.329585075378411.9660186767578
12043OLFOlfactory bulb13.717899322509811.535457611084
12043PPons9.7641477584838910.2291431427002
12043PALPallidum4.701626777648933.91455054283142
12043RHPRetrohippocampal region1.754171490669251.12898993492126
12043sAMYStriatum-like amygdalar nuclei6.286775588989264.15601587295532
12043STRStriatum3.559837579727172.39918637275696
12043STRdStriatum dorsal region3.365452527999882.28249001502991
12043STRvStriatum ventral region3.686298131942752.31742978096008
12043THThalamus7.670720577239996.44489049911499
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
596GO:0000074TASProcessregulation of progression through cell cycle
596GO:0001836NASProcessrelease of cytochrome c from mitochondria
596GO:0005634IEAComponentnucleus
596GO:0005739IEAComponentmitochondrion
596GO:0005741IDAComponentmitochondrial outer membrane
596GO:0005741TASComponentmitochondrial outer membrane
596GO:0005783IEAComponentendoplasmic reticulum
596GO:0006916IDAProcessanti-apoptosis
596GO:0006959TASProcesshumoral immune response
596GO:0008285TASProcessnegative regulation of cell proliferation
596GO:0016020IEAComponentmembrane
596GO:0016021IEAComponentintegral to membrane
596GO:0042802IPIFunctionidentical protein binding
596GO:0042981IEAProcessregulation of apoptosis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-27113AAK39543.1Homo sapiens PUMA beta mRNA, complete cds.BIND196459
-63970BAB16421.1p53AIP1HPRD10397
-7159CAC83012.1ASPP2 proteinHPRD11803
-6606NP_000335.1survival of motor neuron 1, telomeric isoform dHPRD02646
-637NP_001187.1BH3 interacting domain death agonist isoform 2HPRD03590
-637NP_001187.1BH3 interacting domain death agonist isoform 2BIND193177
-841NP_001219.2caspase 8 isoform AHPRD03459
-640NP_001706.2B lymphoid tyrosine kinaseHPRD01866
-1017NP_001789.2cyclin-dependent kinase 2 isoform 1HPRD00310
-4893NP_002515.1neuroblastoma RAS viral (v-ras) oncogene homologHPRD01273
-5894NP_002871.1v-raf-1 murine leukemia viral oncogene homolog 1HPRD01265
-7009NP_003208.1testis enhanced gene transcript (BAX inhibitor 1)HPRD02851
-9088NP_004194.2membrane-associated tyrosine- and threonine-specific cdc2-inhibiHPRD03920
-9531NP_004272.2BCL2-associated athanogene 3HPRD04860
-9531NP_004272.2BCL2-associated athanogene 3BIND259421
-836NP_004337.2caspase 3 preproproteinHPRD02799
-7536NP_004621.1splicing factor 1HPRD03306
-9530NP_004865.1BCL2-associated athanogene 4HPRD04861
-9530NP_004865.1BCL2-associated athanogene 4BIND259422
-3265NP_005334.1v-Ha-ras Harvey rat sarcoma viral oncogene homolog isofrom 1HPRD01813
-5525NP_006234.1protein phosphatase 2, regulatory subunit B (B56), alpha isoformHPRD03384
-27113NP_055232.1BCL2 binding component 3HPRD16165
-27113NP_055232.1BCL2 binding component 3BIND196458
-27113NP_055232.1BCL2 binding component 3BIND193182
-9804NP_055580.1translocase of outer mitochondrial membrane 20 homologHPRD03507
-54205NP_061820.1cytochrome cHPRD00479
-10017NP_065129.1BCL2-like 10 (apoptosis facilitator)HPRD06071
-9445NP_068839.1integral membrane protein 2BHPRD04878
-3845NP_203524.1c-K-ras2 protein isoform aHPRD01817
-90427NP_277038.1Bcl2 modifying factor isoform bmf-1HPRD05881
-149428NP_612122.1BCL2/adenovirus E1B 19kD interacting protein like isoform 1HPRD16557
-598NP_612815.1BCL2-like 1 isoform 1HPRD02497
-10018NP_619527.1BCL2-like 11 isoform 1HPRD04828
-79370NP_620048.1BCL2-like 14 isoform 1HPRD05841
-57142NP_722550.1reticulon 4 isoform BBIND197379
NC_000018.8---BIND123326
NP_000624.1--PP2AHPRD01045
NP_000624.1--PP2AcHPRD01045
NP_000624.1--HSP 72HPRD01045
NP_000624.1--MOAP1HPRD01045
NP_000624.1--RTN-XSHPRD01045
NP_000624.1--Isoenzyme 9-2 of 2-5(A) synthetaseHPRD01045
NP_000624.1--PP1alphaHPRD01045
NP_000624.1--PUMAHPRD01045
NP_000624.1--p53AIP1HPRD01045
NP_000624.1--BNIPLHPRD01045
NP_000624.17159-Tumor protein p53 binding protein 2HPRD01045
NP_000624.17536-Splicing factor 1HPRD01045
NP_000624.15894-RAF1HPRD01045
NP_000624.19804-TOM20HPRD01045
NP_000624.16606-Survival of motor neuron 1, telomericHPRD01045
NP_000624.110018-BCL2 interacting protein BIMHPRD01045
NP_000624.1640-BLKHPRD01045
NP_000624.17009-Bax inhibitor 1HPRD01045
NP_000624.1637-BH3 interacting domain death agonistHPRD01045
NP_000624.15515-Protein phosphatase 2A, catalytic subunit, alpha isoformHPRD01045
NP_000624.13303-Heat shock 70 KD protein 1AHPRD01045
NP_000624.13265-H-RasHPRD01045
NP_000624.13845-Kirsten RAS1HPRD01045
NP_000624.14893-NRASHPRD01045
NP_000624.154205-Cytochrome CHPRD01045
NP_000624.179370-Apoptosis regulator BCLGHPRD01045
NP_000624.110017-BCL2 like 10HPRD01045
NP_000624.19088-MYT1HPRD01045
NP_000624.1841-Caspase 8HPRD01045
NP_000624.19531-BCL2 associated athanogene 3HPRD01045
NP_000624.19530-SODDHPRD01045
NP_000624.190427-Bcl2 modifying factorHPRD01045
NP_000624.1598-BCLXHPRD01045
NP_000624.15525-Protein phosphatase 2, regulatory subunit B (B56), alphaHPRD01045
NP_000624.1836-Caspase 3HPRD01045
NP_000624.163970-p53 regulated apoptosis inducing protein 1HPRD01045
NP_000624.19445-Integral membrane protein 2BHPRD01045
NP_000624.1149428-BCL2/adenovirus E1B 19kD interacting protein likeHPRD01045
NP_000624.13164-Nuclear receptor subfamily 4,group A, member 1HPRD01045
NP_000624.15594-ERK2HPRD01045
NP_000624.16647-SOD1HPRD01045
NP_000624.11017-Cyclin dependent kinase 2HPRD01045
NP_000624.15600AAB05036.1Human p38B MAP kinase mRNA, and translated productsHPRD01045
NP_000624.1149428AAK54348.1Bcl-2/adenovirus E1B 19 kDa interacting protein 2 like-2BIND196758
NP_000624.15663NP_000012.1presenilin 1HPRD01045
NP_000624.17157NP_000537.2tumor protein p53HPRD01045
NP_000624.1596NP_000624.1B-cell lymphoma protein 2 alpha isoformHPRD01045
NP_000624.15530NP_000935.1protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)HPRD00234
NP_000624.15530NP_000935.1protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)HPRD01045
NP_000624.190427NP_001003940.1Bcl2 modifying factor isoform bmf-1BIND209427
NP_000624.15499NP_001008709.1protein phosphatase 1, catalytic subunit, alpha isoform 3HPRD15942
NP_000624.1637NP_001187.1BH3 interacting domain death agonist isoform 2BIND209444
NP_000624.1638NP_001188.1BCL2-interacting killerBIND146453
NP_000624.1638NP_001188.1BCL2-interacting killerHPRD01045
NP_000624.1638NP_001188.1BCL2-interacting killerHPRD04547
NP_000624.1638NP_001188.1BCL2-interacting killerBIND210094
NP_000624.18678NP_003757.1beclin 1HPRD05087
NP_000624.18678NP_003757.1beclin 1HPRD01045
NP_000624.18739NP_003797.1harakiriHPRD04581
NP_000624.18739NP_003797.1harakiriHPRD01045
NP_000624.18739NP_003797.1harakiriBIND146198
NP_000624.18739NP_003797.1harakiriBIND209445
NP_000624.1664NP_004043.2BCL2/adenovirus E1B 19kD-interacting protein 3HPRD04482
NP_000624.1664NP_004043.2BCL2/adenovirus E1B 19kD-interacting protein 3HPRD01045
NP_000624.1663NP_004321.1BCL2/adenovirus E1B 19kD interacting protein 2HPRD04481
NP_000624.1663NP_004321.1BCL2/adenovirus E1B 19kD interacting protein 2HPRD01045
NP_000624.1665NP_004322.1BCL2/adenovirus E1B 19kD-interacting protein 3-likeHPRD07288
NP_000624.1665NP_004322.1BCL2/adenovirus E1B 19kD-interacting protein 3-likeHPRD01045
NP_000624.15883NP_004575.1RAD9 homologHPRD04788
NP_000624.15883NP_004575.1RAD9 homologHPRD01045
NP_000624.16009NP_005605.1Ras homolog enriched in brainBIND146454
NP_000624.110134NP_005736.3B-cell receptor-associated protein 31HPRD02319
NP_000624.110134NP_005736.3B-cell receptor-associated protein 31HPRD01045
NP_000624.15300NP_006212.1protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1HPRD03031
NP_000624.15300NP_006212.1protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1HPRD01045
NP_000624.16237NP_006261.1related RAS viral (r-ras) oncogene homologHPRD01299
NP_000624.16237NP_006261.1related RAS viral (r-ras) oncogene homologHPRD01045
NP_000624.110018NP_006529.1BCL2-like 11 isoform 6BIND210089
NP_000624.123770NP_036313.2FK506-binding protein 8HPRD05327
NP_000624.123770NP_036313.2FK506-binding protein 8HPRD01045
NP_000624.1662NP_053583.1BCL2/adenovirus E1B 19kD interacting protein 1 isoform BNIP1-cHPRD04480
NP_000624.1662NP_053583.1BCL2/adenovirus E1B 19kD interacting protein 1 isoform BNIP1-cHPRD01045
NP_000624.127113NP_055232.1BCL2 binding component 3BIND210088
NP_000624.19774NP_055554.1BCL2-associated transcription factor 1HPRD16544
NP_000624.19774NP_055554.1BCL2-associated transcription factor 1HPRD01045
NP_000624.151283NP_057645.1apoptosis regulatorHPRD16548
NP_000624.151283NP_057645.1apoptosis regulatorHPRD01045
NP_000624.157142NP_065393.1reticulon 4 isoform AHPRD07259
NP_000624.157142NP_065393.1reticulon 4 isoform AHPRD01045
NP_000624.15366NP_066950.1phorbol-12-myristate-13-acetate-induced protein 1HPRD12002
NP_000624.15366NP_066950.1phorbol-12-myristate-13-acetate-induced protein 1HPRD01045
NP_000624.164112NP_071434.2modulator of apoptosis 1HPRD01045
NP_000624.164112NP_071434.2modulator of apoptosis 1HPRD17580
NP_000624.183985NP_114427.1spinsterHPRD11599
NP_000624.183985NP_114427.1spinsterHPRD01045
NP_000624.1155807NP_057852.2Vpr--
NP_000624.1155807NP_057852.2Vpr--
NP_000624.1155871NP_057853.1Tat--
NP_000624.1155871NP_057853.1Tat--
NP_000648.164112NP_071434.2modulator of apoptosis 1BIND153635
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
596BCL2_HUMANP10415IPR002475BCL2_apoptsisBCL2-like apoptosis inhibitor
596BCL2_HUMANP10415IPR000712Bcl2_BHApoptosis regulator Bcl-2, BH
596BCL2_HUMANP10415IPR003093Bcl2_BH4Apoptosis regulator Bcl-2 protein, BH4

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