Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5977
Official Symbol:DPF2
Other Aliases:MGC10180|REQ|UBID4|ubi-d4
See related:HGNC:9964|MIM:601671|HPRD:03394
Chromosome:11
Location:11q13
Gene Description:D4, zinc and double PHD fingers family 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0883
ORGANISM:human
Entrez Gene ID:5977
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.5 :: -1.5 :: -1.3
KARG Evidence 2
KARG ID:QTL0249
ORGANISM:human
Entrez Gene ID:5977
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19708CBCerebellum30.378631591796928.7924766540527
19708CTXCerebral cortex58.567073822021527.7407550811768
19708HIPHippocampal region41.439083099365231.8658256530762
19708HPFHippocampal formation56.764137268066437.3336906433105
19708HYHypothalamus29.063352584838915.8375663757324
19708LSXLateral septal complex9.33679199218754.05224990844727
19708MBMidbrain23.556032180786113.448390007019
19708MYMedulla47.09260177612336.0095710754395
19708OLFOlfactory bulb72.481452941894544.5568351745605
19708PPons40.07134628295931.7296581268311
19708PALPallidum36.638359069824222.8972206115723
19708RHPRetrohippocampal region90.785842895507849.2563858032227
19708sAMYStriatum-like amygdalar nuclei57.259471893310527.2577877044678
19708STRStriatum47.334354400634822.006290435791
19708STRdStriatum dorsal region52.891803741455123.7197151184082
19708STRvStriatum ventral region44.388225555419923.6869602203369
19708THThalamus22.142436981201211.2979955673218
KARG Evidence 3
KARG ID:QTL0249
Trait:METH responses for body temperature
Peak:2
Peak Marker:Lybp2
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:8987796
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5977GO:0003676IEAFunctionnucleic acid binding
5977GO:0005515IEAFunctionprotein binding
5977GO:0005634IEAComponentnucleus
5977GO:0006350IEAProcesstranscription
5977GO:0006355IEAProcessregulation of transcription, DNA-dependent
5977GO:0006915IEAProcessapoptosis
5977GO:0008270IEAFunctionzinc ion binding
5977GO:0008624TASProcessinduction of apoptosis by extracellular signals
5977GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5977REQU_HUMANQ92785IPR007087Znf_C2H2Zinc finger, C2H2-type
5977REQU_HUMANQ92785IPR001965Znf_PHDZinc finger, PHD-type

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