Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:598
Official Symbol:BCL2L1
Other Aliases:BCL-XL/S|BCL2L|BCLX|Bcl-X|DKFZp781P2092|bcl-xL|bcl-xS
See related:HGNC:992|MIM:600039|HPRD:02497
Chromosome:20
Location:20q11.21
Gene Description:BCL2-like 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0392
ORGANISM:human
Entrez Gene ID:598
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24888
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12048CBCerebellum46.010437011718878.369010925293
12048CTXCerebral cortex100.096.059944152832
12048HIPHippocampal region70.4874267578125100.0
12048HPFHippocampal formation70.627952575683697.3016738891602
12048HYHypothalamus89.371025085449280.641960144043
12048LSXLateral septal complex95.300727844238381.882080078125
12048MBMidbrain81.017944335937581.016471862793
12048MYMedulla79.76403045654391.9678421020508
12048OLFOlfactory bulb94.003425598144590.8705520629883
12048PPons79.49353790283289.1846542358398
12048PALPallidum80.46788787841878.8919677734375
12048RHPRetrohippocampal region72.124092102050863.8355712890625
12048sAMYStriatum-like amygdalar nuclei83.197677612304766.468376159668
12048STRStriatum73.043495178222757.359130859375
12048STRdStriatum dorsal region67.503738403320353.1351470947266
12048STRvStriatum ventral region76.232574462890654.8148384094238
12048THThalamus84.843826293945379.8553619384766
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
598GO:0005739TASComponentmitochondrion
598GO:0005741NASComponentmitochondrial outer membrane
598GO:0006916TASProcessanti-apoptosis
598GO:0008634TASProcessnegative regulation of survival gene product activity
598GO:0008637TASProcessapoptotic mitochondrial changes
598GO:0016020IEAComponentmembrane
598GO:0016021IEAComponentintegral to membrane
598GO:0042802IPIFunctionidentical protein binding
598GO:0042981IEAProcessregulation of apoptosis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6622NP_000336.1alpha-synuclein isoform NACP140HPRD01227
-5664NP_000438.1presenilin 2 isoform 1HPRD02860
-5499NP_001008709.1protein phosphatase 1, catalytic subunit, alpha isoform 3HPRD15942
-841NP_001219.2caspase 8 isoform AHPRD03459
-842NP_001220.2caspase 9 isoform alpha preproproteinHPRD03756
-7009NP_003208.1testis enhanced gene transcript (BAX inhibitor 1)HPRD02851
-8660NP_003740.2insulin receptor substrate 2HPRD02878
-8837NP_003870.3CASP8 and FADD-like apoptosis regulatorHPRD04671
-8837NP_003870.3CASP8 and FADD-like apoptosis regulatorBIND195914
-664NP_004043.2BCL2/adenovirus E1B 19kD-interacting protein 3HPRD04482
-3667NP_005535.1insulin receptor substrate 1HPRD00943
-22806NP_036613.1zinc finger protein, subfamily 1A, 3 (Aiolos)HPRD05869
-54205NP_061820.1cytochrome cHPRD00479
-57099NP_065104.1cell death regulator avenHPRD05588
-84168NP_115584.1tumor endothelial marker 8 isoform 1 precursorHPRD05913
-10018NP_619527.1BCL2-like 11 isoform 1HPRD04828
-79370NP_620048.1BCL2-like 14 isoform 1HPRD05841
NP_001182.11409NP_000385.1crystallin, alpha ABIND185554
NP_001182.11410NP_001876.1crystallin, alpha BBIND185557
NP_612815.1--RTN-XsHPRD02497
NP_612815.1--PP1 alphaHPRD02497
NP_612815.18739-BCL2 interacting proteinHPRD02497
NP_612815.154205-Cytochrome CHPRD02497
NP_612815.18837-c-FLIPHPRD02497
NP_612815.110018-BCL2 interacting protein BIMHPRD02497
NP_612815.1842-Caspase 9HPRD02497
NP_612815.17009-Bax inhibitor 1HPRD02497
NP_612815.15664-Presenilin 2HPRD02497
NP_612815.1664-Bcl2/adenovirus E1B 19 kD protein interacting protein 3HPRD02497
NP_612815.13667-IRS 1HPRD02497
NP_612815.18660-IRS2HPRD02497
NP_612815.157099-Cell death regulator AvenHPRD02497
NP_612815.179370-Apoptosis regulator BCLGHPRD02497
NP_612815.184168-Tumor endothelial marker 8HPRD02497
NP_612815.122806-Zinc finger protein, subfamily 1A, member 3HPRD02497
NP_612815.1841-Caspase 8HPRD02497
NP_612815.16622-Synuclein alphaHPRD02497
NP_612815.1637--BIND216030
NP_612815.110018--BIND216031
NP_612815.15663NP_000012.1presenilin 1HPRD02497
NP_612815.17157NP_000537.2tumor protein p53HPRD02497
NP_612815.17157NP_000537.2tumor protein p53BIND57957
NP_612815.190427NP_001003940.1Bcl2 modifying factor isoform bmf-1BIND209443
NP_612815.190427NP_001003940.1Bcl2 modifying factor isoform bmf-1BIND216034
NP_612815.1637NP_001187.1BH3 interacting domain death agonist isoform 2BIND151034
NP_612815.1637NP_001187.1BH3 interacting domain death agonist isoform 2BIND193178
NP_612815.1637NP_001187.1BH3 interacting domain death agonist isoform 2BIND209441
NP_612815.1638NP_001188.1BCL2-interacting killerHPRD02497
NP_612815.1638NP_001188.1BCL2-interacting killerHPRD04547
NP_612815.1638NP_001188.1BCL2-interacting killerBIND210091
NP_612815.1638NP_001188.1BCL2-interacting killerBIND216032
NP_612815.17178NP_003286.1tumor protein, translationally-controlled 1BIND316058
NP_612815.17416NP_003365.1voltage-dependent anion channel 1HPRD02497
NP_612815.17416NP_003365.1voltage-dependent anion channel 1HPRD05137
NP_612815.18678NP_003757.1beclin 1HPRD05087
NP_612815.18678NP_003757.1beclin 1HPRD02497
NP_612815.18739NP_003797.1harakiriHPRD04581
NP_612815.18739NP_003797.1harakiriHPRD02497
NP_612815.18739NP_003797.1harakiriBIND146199
NP_612815.18739NP_003797.1harakiriBIND209442
NP_612815.18739NP_003797.1harakiriBIND216035
NP_612815.1665NP_004322.1BCL2/adenovirus E1B 19kD-interacting protein 3-likeHPRD07288
NP_612815.1665NP_004322.1BCL2/adenovirus E1B 19kD-interacting protein 3-likeHPRD02497
NP_612815.110134NP_005736.3B-cell receptor-associated protein 31HPRD02319
NP_612815.110134NP_005736.3B-cell receptor-associated protein 31HPRD02497
NP_612815.110572NP_006418.2CD27-binding (Siva) protein isoform 1HPRD16124
NP_612815.110572NP_006418.2CD27-binding (Siva) protein isoform 1HPRD02497
NP_612815.110018NP_006529.1BCL2-like 11 isoform 6BIND210096
NP_612815.123770NP_036313.2FK506-binding protein 8HPRD05327
NP_612815.123770NP_036313.2FK506-binding protein 8HPRD02497
NP_612815.1662NP_053583.1BCL2/adenovirus E1B 19kD interacting protein 1 isoform BNIP1-cHPRD04480
NP_612815.1662NP_053583.1BCL2/adenovirus E1B 19kD interacting protein 1 isoform BNIP1-cHPRD02497
NP_612815.127113NP_055232.1BCL2 binding component 3BIND193183
NP_612815.127113NP_055232.1BCL2 binding component 3BIND210093
NP_612815.127113NP_055232.1BCL2 binding component 3BIND216036
NP_612815.19774NP_055554.1BCL2-associated transcription factor 1HPRD16544
NP_612815.19774NP_055554.1BCL2-associated transcription factor 1HPRD02497
NP_612815.110017NP_065129.1BCL2-like 10 (apoptosis facilitator)HPRD02497
NP_612815.157142NP_065393.1reticulon 4 isoform AHPRD07259
NP_612815.157142NP_065393.1reticulon 4 isoform AHPRD02497
NP_612815.15366NP_066950.1phorbol-12-myristate-13-acetate-induced protein 1HPRD12002
NP_612815.15366NP_066950.1phorbol-12-myristate-13-acetate-induced protein 1HPRD02497
NP_612815.16252NP_066959.1reticulon 1 isoform AHPRD02921
NP_612815.16252NP_066959.1reticulon 1 isoform AHPRD02497
NP_612815.164112NP_071434.2modulator of apoptosis 1HPRD17580
NP_612815.164112NP_071434.2modulator of apoptosis 1HPRD02497
NP_612815.164112NP_071434.2modulator of apoptosis 1BIND153634
NP_612815.183985NP_114427.1spinsterHPRD11599
NP_612815.183985NP_114427.1spinsterHPRD02497
NP_612815.157142NP_722550.1reticulon 4 isoform BBIND197378
NP_612815.1637NP_932070.1BH3 interacting domain death agonist isoform 1BIND151035
NP_612815.16252NP_996734.1reticulon 1 isoform CBIND197377
NP_612815.1155807NP_057852.2Vpr--
NP_612815.1155807NP_057852.2Vpr--
NP_612815.1155871NP_057853.1Tat--
NP_612815.1155945NP_057855.1Vpu--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
598IPR002475BCL2_apoptsisBCL2-like apoptosis inhibitor
598IPR000712Bcl2_BHApoptosis regulator Bcl-2, BH
598IPR003093Bcl2_BH4Apoptosis regulator Bcl-2 protein, BH4
598BCLX_HUMANQ07817IPR002475BCL2_apoptsisBCL2-like apoptosis inhibitor
598BCLX_HUMANQ07817IPR000712Bcl2_BHApoptosis regulator Bcl-2, BH
598BCLX_HUMANQ07817IPR003093Bcl2_BH4Apoptosis regulator Bcl-2 protein, BH4

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.