Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5999
Official Symbol:RGS4
Other Aliases:MGC2124|MGC60244|RGP4
See related:HGNC:10000|MIM:602516|HPRD:03947
Chromosome:1
Location:1q23.3
Gene Description:regulator of G-protein signalling 4
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0489
ORGANISM:human
Entrez Gene ID:5999
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:29480
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0869
ORGANISM:human
Entrez Gene ID:5999
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.5 :: 1.8 :: 2.8
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19736CBCerebellum9.1703536510467510.8095813592275
19736CTXCerebral cortex100.0100.0
19736HIPHippocampal region41.783340454101655.8256092071533
19736HPFHippocampal formation58.065386454264364.7593053181966
19736HYHypothalamus34.895269393920938.4268131256104
19736LSXLateral septal complex21.923627376556422.474568049113
19736MBMidbrain22.624784469604525.7305355072021
19736MYMedulla35.77853838602757.8282432556152
19736OLFOlfactory bulb85.366416931152387.002311706543
19736PPons33.314320246378652.888479868571
19736PALPallidum41.942701339721752.2976048787435
19736RHPRetrohippocampal region83.284509023030679.3373845418294
19736sAMYStriatum-like amygdalar nuclei60.702287038167358.9969278971354
19736STRStriatum100.0100.0
19736STRdStriatum dorsal region100.0100.0
19736STRvStriatum ventral region92.381759643554789.0959726969401
19736THThalamus81.5838343302409100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5999GO:0000188TASProcessinactivation of MAPK activity
5999GO:0004871IEAFunctionsignal transducer activity
5999GO:0005096TASFunctionGTPase activator activity
5999GO:0005516TASFunctioncalmodulin binding
5999GO:0008277TASProcessregulation of G-protein coupled receptor protein signaling pathway
5999GO:0009968IEAProcessnegative regulation of signal transduction
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-23236NP_056007.1phosphoinositide-specific phospholipase C beta 1 isoform aHPRD06177
NP_005604.1--GbetagammaHPRD03947
NP_005604.123236-Phospholipase C, beta 1HPRD03947
NP_005604.19276NP_004757.1coatomer protein complex, subunit beta 2 (beta prime)HPRD06103
NP_005604.19276NP_004757.1coatomer protein complex, subunit beta 2 (beta prime)HPRD03947
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5999RGS4_HUMANP49798IPR000342RGSRegulator of G protein signalling

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