Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:60
Official Symbol:ACTB
Other Aliases:PS1TP5BP1
See related:HGNC:132|MIM:102630|HPRD:00032
Chromosome:7
Location:7p15-p12
Gene Description:actin, beta
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0444
ORGANISM:human
Entrez Gene ID:60
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:81822
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11461CBCerebellum100.0100.0
11461CTXCerebral cortex100.0100.0
11461HIPHippocampal region100.0100.0
11461HPFHippocampal formation100.0100.0
11461HYHypothalamus100.0100.0
11461LSXLateral septal complex100.0100.0
11461MBMidbrain100.0100.0
11461MYMedulla100.0100.0
11461OLFOlfactory bulb100.0100.0
11461PPons100.0100.0
11461PALPallidum100.0100.0
11461RHPRetrohippocampal region100.0100.0
11461sAMYStriatum-like amygdalar nuclei100.0100.0
11461STRStriatum100.0100.0
11461STRdStriatum dorsal region100.0100.0
11461STRvStriatum ventral region100.0100.0
11461THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
60GO:0000166IEAFunctionnucleotide binding
60GO:0005200IEAFunctionstructural constituent of cytoskeleton
60GO:0005515IPIFunctionprotein binding
60GO:0005524IEAFunctionATP binding
60GO:0005856IEAComponentcytoskeleton
60GO:0005884IEAComponentactin filament
60GO:0035267IDAComponentTIP60 histone acetyltransferase complex
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2010NP_000108.1emerinHPRD02309
-2934NP_000168.1gelsolin isoform a precursorHPRD00674
-4687NP_000256.1neutrophil cytosolic factor 1HPRD01990
-5027NP_002553.2purinergic receptor P2X7HPRD03977
-5201NP_002613.2prefoldin subunit 1HPRD05357
-5337NP_002653.1phospholipase D1, phophatidylcholine-specificHPRD03855
-5338NP_002654.2phospholipase D2HPRD03857
-5764NP_002816.1pleiotrophinHPRD01199
-5880NP_002863.1ras-related C3 botulinum toxin substrate 2HPRD03628
-6597NP_003063.2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4HPRD04459
-6709NP_003118.1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)HPRD01684
-7169NP_003280.2tropomyosin 2 (beta) isoform 1HPRD11768
-7430NP_003370.2villin 2HPRD00475
-8655NP_003737.1dynein light chain 1HPRD03334
-70NP_005150.1cardiac muscle alpha actin proproteinHPRD00015
-10694NP_006576.2chaperonin containing TCP1, subunit 8 (theta)HPRD10816
-22948NP_036205.1chaperonin containing TCP1, subunit 5 (epsilon)HPRD06468
-25932NP_039234.1chloride intracellular channel 4HPRD05943
-55333NP_060843.1synaptojanin 2 binding proteinHPRD15455
-5879NP_061485.1ras-related C3 botulinum toxin substrate 1 isoform Rac1bHPRD03627
-4892NP_932326.2nebulin-related anchoring protein isoform SHPRD04189
-7170P06753Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma) (hTM5).HPRD01840
NP_001092.1--VILIPHPRD00032
NP_001092.1--beta cap73HPRD00032
NP_001092.1--Tm1HPRD00032
NP_001092.1--Tm2HPRD00032
NP_001092.1--Tm3HPRD00032
NP_001092.1--HRpIClnHPRD00032
NP_001092.1--CCT thetaHPRD00032
NP_001092.1--EF1 alphaHPRD00032
NP_001092.1--Neurocalcin deltaHPRD00032
NP_001092.1--NaV1.8HPRD00032
NP_001092.17430-EzrinHPRD00032
NP_001092.170-Actin alpha, cardiac muscleHPRD00032
NP_001092.16709-SpectrinHPRD00032
NP_001092.14892-Nebulin related anchoring proteinHPRD00032
NP_001092.15764-PleiotrophinHPRD00032
NP_001092.16597-SMARCA4HPRD00032
NP_001092.12934-GelsolinHPRD00032
NP_001092.14687-p47-phoxHPRD00032
NP_001092.15879-Ras related C3 botulinum toxin substrate 1HPRD00032
NP_001092.15880-Ras related C3 botulinum toxin substrate 2HPRD00032
NP_001092.15337-PLD1HPRD00032
NP_001092.15338-Phospholipase D2HPRD00032
NP_001092.15201-Prefoldin 1HPRD00032
NP_001092.125932-Chloride intracellular channel 4HPRD00032
NP_001092.122948-TCP 1 epsilonHPRD00032
NP_001092.15027-Purinergic receptor P2X, ligand gated ion channel, 7HPRD00032
NP_001092.12010-EmerinHPRD00032
NP_001092.18655-DLC1HPRD00032
NP_001092.14261AC133065.3-BIND180058
NP_001092.160NP_001092.1beta actinBIND180567
NP_001092.12314NP_002009.1flightless I homologHPRD02647
NP_001092.12314NP_002009.1flightless I homologHPRD00032
NP_001092.15216NP_005013.1profilin 1HPRD00032
NP_001092.11773NP_005214.2deoxyribonuclease I precursorBIND217693
NP_001092.110095NP_005711.1actin related protein 2/3 complex subunit 1BHPRD10366
NP_001092.110529NP_006384.1nebulette sarcomeric isoformHPRD10403
NP_001092.110576NP_006422.1chaperonin containing TCP1, subunit 2HPRD00032
NP_001092.110576NP_006422.1chaperonin containing TCP1, subunit 2HPRD06895
NP_001092.126578NP_036515.3osteoclast stimulating factor 1BIND216512
NP_001092.129124NP_037400.1placental protein 13HPRD16375
NP_001092.123214NP_055986.1exportin 6HPRD10525
NP_001092.155257NP_060740.1MRG-binding proteinHPRD16646
NP_001092.154700NP_060897.2RRN3 RNA polymerase I transcription factor homologBIND183466
NP_001092.184172NP_061887.2RNA polymerase I polypeptide BBIND183465
NP_001092.13192NP_114032.1heterogeneous nuclear ribonucleoprotein U isoform aBIND217694
NP_001092.185461NP_203752.1TPR domain, ankyrin-repeat and coiled-coil-containingHPRD18146
NP_001092.15217NP_444252.1profilin 2 isoform aHPRD00032
NP_001092.1131034NP_570720.1copine IVHPRD05017
NP_001092.1131034NP_570720.1copine IVHPRD00032
NP_001092.1137735NP_631905.1striated muscle activator of Rho-dependent signalingHPRD11608
NP_001092.1221184NP_689940.3copine IIHPRD05015
NP_001092.1221184NP_689940.3copine IIHPRD00032
NP_001092.18904NP_690902.1copine IHPRD05014
NP_001092.18904NP_690902.1copine IHPRD00032
NP_001092.1125168U13369.1Human ribosomal DNA complete repeating unit.BIND183469
NP_001092.12537U22970.1Homo sapiens interferon-inducible peptide precursor (6-16) gene, complete cds, alternatively spliced.BIND180061
NP_001092.1155908NP_057854.1Rev--
NP_001092.1155908NP_057854.1Rev--
NP_001092.1155908NP_057854.1Rev--
NP_001092.1155030NP_579881.1nucleocapsid--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
60ACTB_HUMANP60709IPR004001ActinActin
60ACTB_HUMANP60709IPR004000Actin_likeActin/actin-like

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