Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6002
Official Symbol:RGS12
Other Aliases:DKFZp761K1617|DKFZp761K1817
See related:HGNC:9994|MIM:602512|HPRD:03943
Chromosome:4
Location:4p16.3
Gene Description:regulator of G-protein signalling 12
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM1141
ORGANISM:human
Entrez Gene ID:6002
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12716423
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Ventral Tegmental Area
Drug Effects:Downregulated
Fold Change:-
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
71729CBCerebellum21.897082328796448.9421329498291
71729CTXCerebral cortex96.6957664489746100.0
71729HIPHippocampal region29.331173896789650.1452007293701
71729HPFHippocampal formation51.225088119506877.7020797729492
71729HYHypothalamus9.115155205130586.93680064380169
71729LSXLateral septal complex27.611062526702923.498482465744
71729MBMidbrain9.231685638427739.49109017848969
71729MYMedulla16.580127000808718.3448153734207
71729OLFOlfactory bulb71.159543991088976.5636043548584
71729PPons12.392727375030512.827700138092
71729PALPallidum19.984689235687320.6160359382629
71729RHPRetrohippocampal region84.166728973388797.6516914367676
71729sAMYStriatum-like amygdalar nuclei31.748980522155830.2224521636963
71729STRStriatum48.815807342529344.620002746582
71729STRdStriatum dorsal region50.594254493713445.930459022522
71729STRvStriatum ventral region60.012738227844254.1685600280762
71729THThalamus14.125545740127613.0837943553925
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6002GO:0000794TASComponentcondensed nuclear chromosome
6002GO:0005057IEAFunctionreceptor signaling protein activity
6002GO:0005096IEAFunctionGTPase activator activity
6002GO:0005096TASFunctionGTPase activator activity
6002GO:0005515IEAFunctionprotein binding
6002GO:0005634IEAComponentnucleus
6002GO:0007165IEAProcesssignal transduction
6002GO:0008277TASProcessregulation of G-protein coupled receptor protein signaling pathway
6002GO:0009968IEAProcessnegative regulation of signal transduction
6002GO:0015031IEAProcessprotein transport
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-23236NP_056007.1phosphoinositide-specific phospholipase C beta 1 isoform aHPRD06177
NP_937872.123236-Phospholipase C, beta 1HPRD03943
NP_937872.16002NP_937872.1regulator of G-protein signalling 12 isoform 1HPRD03943
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6002IPR003109GoLocoGoLoco
6002IPR001478PDZPDZ/DHR/GLGF
6002IPR006020PTB_PIDPhosphotyrosine interaction region
6002IPR003116Raf_like_ras_bdRaf-like Ras-binding
6002IPR000342RGSRegulator of G protein signalling
6002IPR003979tropoelastinTropoelastin
6002RGS12_HUMANO14924IPR003109GoLocoGoLoco
6002RGS12_HUMANO14924IPR001478PDZPDZ/DHR/GLGF
6002RGS12_HUMANO14924IPR006020PTB_PIDPhosphotyrosine interaction region
6002RGS12_HUMANO14924IPR003116Raf_like_ras_bdRaf-like Ras-binding
6002RGS12_HUMANO14924IPR000342RGSRegulator of G protein signalling

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