Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:610
Official Symbol:HCN2
Other Aliases:BCNG-2|BCNG2|HAC-1
See related:HGNC:4846|MIM:602781|HPRD:07213
Chromosome:19
Location:19p13.3
Gene Description:hyperpolarization activated cyclic nucleotide-gated potassium channel 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0120
ORGANISM:human
Entrez Gene ID:610
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:15166
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
15166CBCerebellum62.981140136718880.5329666137695
15166CTXCerebral cortex35.422573089599629.7722806930542
15166HIPHippocampal region21.163798332214424.0198211669922
15166HPFHippocampal formation23.339974403381323.5835943222046
15166HYHypothalamus51.378595352172945.0026378631592
15166LSXLateral septal complex14.590606689453111.4805524349213
15166MBMidbrain96.497032165527398.5897941589355
15166MYMedulla100.0100.0
15166OLFOlfactory bulb31.4998674392728.6106481552124
15166PPons100.0100.0
15166PALPallidum63.73180389404374.2767944335938
15166RHPRetrohippocampal region27.215689659118723.2138957977295
15166sAMYStriatum-like amygdalar nuclei18.043832778930716.6604957580566
15166STRStriatum21.83011436462418.4441537857056
15166STRdStriatum dorsal region25.04989814758320.681715965271
15166STRvStriatum ventral region17.533926010131816.1819114685059
15166THThalamus99.222774505615298.8346405029297
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
610GO:0000166IEAFunctionnucleotide binding
610GO:0005249IEAFunctionvoltage-gated potassium channel activity
610GO:0005624NRComponentmembrane fraction
610GO:0006812TASProcesscation transport
610GO:0006813IEAProcesspotassium ion transport
610GO:0006814IEAProcesssodium ion transport
610GO:0006936TASProcessmuscle contraction
610GO:0007267TASProcesscell-cell signaling
610GO:0008076TASComponentvoltage-gated potassium channel complex
610GO:0016020IEAComponentmembrane
610GO:0016021IEAComponentintegral to membrane
610GO:0030552IEAFunctioncAMP binding
610GO:0030955IEAFunctionpotassium ion binding
610GO:0031402IEAFunctionsodium ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-348980NP_066550.1hyperpolarization activated cyclic nucleotide-gated potassium channel 1HPRD09099
NP_001185.2--HCN1HPRD07213
NP_001185.2--HCN4HPRD07213
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
610HCN2_HUMANQ9UL51IPR002951AtrophinAtrophin
610HCN2_HUMANQ9UL51IPR002373cAMP_kincAMP-dependent protein kinase
610HCN2_HUMANQ9UL51IPR000595cNMP_bdCyclic nucleotide-binding
610HCN2_HUMANQ9UL51IPR003938EAG_ELK_ERGEAG/ELK/ERG potassium channel
610HCN2_HUMANQ9UL51IPR001376GliadinGliadin, alpha/beta
610HCN2_HUMANQ9UL51IPR005821Ion_transIon transport
610HCN2_HUMANQ9UL51IPR013621Ion_trans_NIon transport N-terminal
610HCN2_HUMANQ9UL51IPR001622K+channel_poreK+ channel, pore region
610HCN2_HUMANQ9UL51IPR005820M+channel_nlgCation channel, non-ligand gated
610HCN2_HUMANQ9UL51IPR006030Mollsc_rhodpsn_CMolluscan rhodopsin C-terminal tail
610HCN2_HUMANQ9UL51IPR000694PRO_richProline-rich region

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.