Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6195
Official Symbol:RPS6KA1
Other Aliases:HU-1|MAPKAPK1A|RSK|RSK1|S6K-alpha 1
See related:HGNC:10430|MIM:601684|HPRD:03402
Chromosome:1
Location:1p
Gene Description:ribosomal protein S6 kinase, 90kDa, polypeptide 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0391
ORGANISM:human
Entrez Gene ID:6195
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:81771
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20111CBCerebellum93.4781341552734100.0
20111CTXCerebral cortex22.653722763061516.320240020752
20111HIPHippocampal region7.340056896209727.04475164413452
20111HPFHippocampal formation14.09189319610611.9858388900757
20111HYHypothalamus5.150523185729984.21884393692017
20111LSXLateral septal complex2.856075763702391.91459381580353
20111MBMidbrain12.419798851013212.6423711776733
20111MYMedulla22.198234558105526.9340915679932
20111OLFOlfactory bulb22.805427551269517.2347927093506
20111PPons13.606789588928215.8131132125854
20111PALPallidum9.502925872802738.69241619110107
20111RHPRetrohippocampal region24.8286132812518.4214096069336
20111sAMYStriatum-like amygdalar nuclei3.553898096084592.72188901901245
20111STRStriatum3.388461351394652.58309102058411
20111STRdStriatum dorsal region2.158443212509161.73297142982483
20111STRvStriatum ventral region6.627776622772224.4359073638916
20111THThalamus10.97358322143559.40427684783936
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6195GO:0000166IEAFunctionnucleotide binding
6195GO:0004672IEAFunctionprotein kinase activity
6195GO:0004674IEAFunctionprotein serine/threonine kinase activity
6195GO:0004674TASFunctionprotein serine/threonine kinase activity
6195GO:0004713IEAFunctionprotein-tyrosine kinase activity
6195GO:0005524IEAFunctionATP binding
6195GO:0006468IEAProcessprotein amino acid phosphorylation
6195GO:0007165TASProcesssignal transduction
6195GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7529NP_003395.1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideHPRD03184
NP_002944.2--TOB2HPRD03402
NP_002944.21449453NP_863509.1Yop effector YopMBIND144344
NP_002944.27529-14-3-3 BetaHPRD03402
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6195IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
6195IPR000961Pkinase_CProtein kinase, C-terminal
6195IPR000719Prot_kinaseProtein kinase
6195IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
6195IPR001245Tyr_pkinaseTyrosine protein kinase
6195IPR013695WAKWall-associated kinase
6195KS6A1_HUMANQ15418IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
6195KS6A1_HUMANQ15418IPR000961Pkinase_CProtein kinase, C-terminal
6195KS6A1_HUMANQ15418IPR000719Prot_kinaseProtein kinase
6195KS6A1_HUMANQ15418IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
6195KS6A1_HUMANQ15418IPR001245Tyr_pkinaseTyrosine protein kinase
6195KS6A1_HUMANQ15418IPR013695WAKWall-associated kinase

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