Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6199
Official Symbol:RPS6KB2
Other Aliases:KLS|P70-beta|P70-beta-1|P70-beta-2|S6K-beta2|S6K2|SRK|STK14B|p70(S6K)-beta|p70S6Kb
See related:HGNC:10437|MIM:608939|HPRD:10203
Chromosome:11
Location:11q13.1
Gene Description:ribosomal protein S6 kinase, 70kDa, polypeptide 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0366
ORGANISM:human
Entrez Gene ID:6199
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.1 :: -1.3 :: -1.4 :: -1.5 :: -1.6 :: -1.7
KARG Evidence 2
KARG ID:EVIM0434
ORGANISM:human
Entrez Gene ID:6199
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.1 :: 1 :: -1.3 :: -2.7 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
58988CBCerebellum100.0100.0
58988CTXCerebral cortex100.0100.0
58988HIPHippocampal region100.0100.0
58988HPFHippocampal formation100.0100.0
58988HYHypothalamus100.0100.0
58988LSXLateral septal complex100.0100.0
58988MBMidbrain100.0100.0
58988MYMedulla100.0100.0
58988OLFOlfactory bulb100.0100.0
58988PPons100.0100.0
58988PALPallidum100.0100.0
58988RHPRetrohippocampal region100.0100.0
58988sAMYStriatum-like amygdalar nuclei100.0100.0
58988STRStriatum100.0100.0
58988STRdStriatum dorsal region100.0100.0
58988STRvStriatum ventral region100.0100.0
58988THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6199GO:0000074TASProcessregulation of progression through cell cycle
6199GO:0000166IEAFunctionnucleotide binding
6199GO:0004672IEAFunctionprotein kinase activity
6199GO:0004674IEAFunctionprotein serine/threonine kinase activity
6199GO:0004674TASFunctionprotein serine/threonine kinase activity
6199GO:0004713IEAFunctionprotein-tyrosine kinase activity
6199GO:0005524IEAFunctionATP binding
6199GO:0006412TASProcessprotein biosynthesis
6199GO:0006468IEAProcessprotein amino acid phosphorylation
6199GO:0007165TASProcesssignal transduction
6199GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6199IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
6199IPR000719Prot_kinaseProtein kinase
6199IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
6199IPR001245Tyr_pkinaseTyrosine protein kinase
6199IPR013695WAKWall-associated kinase
6199KS6B2_HUMANQ9UBS0IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
6199KS6B2_HUMANQ9UBS0IPR000961Pkinase_CProtein kinase, C-terminal
6199KS6B2_HUMANQ9UBS0IPR000719Prot_kinaseProtein kinase
6199KS6B2_HUMANQ9UBS0IPR000694PRO_richProline-rich region
6199KS6B2_HUMANQ9UBS0IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
6199KS6B2_HUMANQ9UBS0IPR001245Tyr_pkinaseTyrosine protein kinase
6199KS6B2_HUMANQ9UBS0IPR013695WAKWall-associated kinase

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