Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6252
Official Symbol:RTN1
Other Aliases:MGC133250|NSP
See related:HGNC:10467|MIM:600865|HPRD:02921
Chromosome:14
Location:14q23.1
Gene Description:reticulon 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0023
ORGANISM:human
Entrez Gene ID:6252
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:104001
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0400
ORGANISM:human
Entrez Gene ID:6252
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1 :: 1.1 :: 1.7 :: 1.1 :: -1 :: -1.5
KARG Evidence 3
KARG ID:EVIM0468
ORGANISM:human
Entrez Gene ID:6252
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.4 :: -1.4 :: -1.4 :: -1 :: -1
KARG Evidence 4
KARG ID:EVIM0927
ORGANISM:human
Entrez Gene ID:6252
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.4 :: 1.4 :: 1.4 :: 1.3
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
104001CBCerebellum100.0100.0
104001CTXCerebral cortex100.0100.0
104001HIPHippocampal region100.0100.0
104001HPFHippocampal formation100.0100.0
104001HYHypothalamus100.0100.0
104001LSXLateral septal complex100.0100.0
104001MBMidbrain100.0100.0
104001MYMedulla97.7682342529297100.0
104001OLFOlfactory bulb100.0100.0
104001PPons99.6134796142578100.0
104001PALPallidum100.0100.0
104001RHPRetrohippocampal region100.0100.0
104001sAMYStriatum-like amygdalar nuclei100.0100.0
104001STRStriatum100.0100.0
104001STRdStriatum dorsal region100.0100.0
104001STRvStriatum ventral region100.0100.0
104001THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6252GO:0004871NASFunctionsignal transducer activity
6252GO:0005554IEAFunctionmolecular function unknown
6252GO:0005783IEAComponentendoplasmic reticulum
6252GO:0007165NASProcesssignal transduction
6252GO:0016020IEAComponentmembrane
6252GO:0016021IEAComponentintegral to membrane
6252GO:0030176TASComponentintegral to endoplasmic reticulum membrane
6252GO:0030182TASProcessneuron differentiation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7357NP_003349.1ceramide glucosyltransferaseHPRD04190
NP_066959.17357-Ceramide glucosyltransferaseHPRD02921
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6252IPR005384Duffy_cmk_rcptDuffy antigen/chemokine receptor
6252IPR001951Histone_H4Histone H4
6252IPR003388ReticulonReticulon
6252RTN1_HUMANQ16799IPR001951Histone_H4Histone H4
6252RTN1_HUMANQ16799IPR000694PRO_richProline-rich region
6252RTN1_HUMANQ16799IPR003388ReticulonReticulon

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