Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6258
Official Symbol:RXRG
Other Aliases:NR2B3|RXRC
See related:HGNC:10479|MIM:180247|HPRD:01579
Chromosome:1
Location:1q22-q23
Gene Description:retinoid X receptor, gamma
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0876
ORGANISM:human
Entrez Gene ID:6258
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.4 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20183CBCerebellum84.275493621826269.8492183685303
20183CTXCerebral cortex100.0100.0
20183HIPHippocampal region89.695007324218897.6423568725586
20183HPFHippocampal formation100.098.891658782959
20183HYHypothalamus65.391590118408247.2359180450439
20183LSXLateral septal complex55.15612030029334.6448431015015
20183MBMidbrain86.473865509033267.9393615722656
20183MYMedulla80.277244567871174.3667278289795
20183OLFOlfactory bulb100.0100.0
20183PPons70.038787841796960.1643447875977
20183PALPallidum55.944837570190443.0949993133545
20183RHPRetrohippocampal region100.0100.0
20183sAMYStriatum-like amygdalar nuclei92.689445495605567.2581233978271
20183STRStriatum100.094.709300994873
20183STRdStriatum dorsal region100.0100.0
20183STRvStriatum ventral region100.093.892707824707
20183THThalamus100.088.492919921875
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6258GO:0003700IEAFunctiontranscription factor activity
6258GO:0003707IEAFunctionsteroid hormone receptor activity
6258GO:0004886TASFunctionretinoid-X receptor activity
6258GO:0005496IEAFunctionsteroid binding
6258GO:0005634IEAComponentnucleus
6258GO:0006350IEAProcesstranscription
6258GO:0006355IEAProcessregulation of transcription, DNA-dependent
6258GO:0008270IEAFunctionzinc ion binding
6258GO:0043565IEAFunctionsequence-specific DNA binding
6258GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7068NP_000452.2thyroid hormone receptor, betaHPRD07521
-6722NP_003122.1serum response factor (c-fos serum response element-binding transcription factor)HPRD02788
NP_008848.17068-Thyroid hormone receptor, betaHPRD01579
NP_008848.16722-Serum response factorHPRD01579
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6258
6258RXRG_HUMANP48443IPR003068COUP_TFTranscription factor COUP
6258RXRG_HUMANP48443IPR000536Hrmn_rcpt_lig_bdNuclear hormone receptor, ligand-binding
6258RXRG_HUMANP48443IPR001628Hrmn_rcpt_DNA_bdNuclear hormone receptor, DNA-binding
6258RXRG_HUMANP48443IPR003070Nuc_orph_rcptOrphan nuclear receptor
6258RXRG_HUMANP48443IPR000003RtnoidX_rcptRetinoid X receptor
6258RXRG_HUMANP48443IPR003078Rtnoid_rcptRetinoic acid receptor
6258RXRG_HUMANP48443IPR001723Str_hrmn_rcptSteroid hormone receptor
6258RXRG_HUMANP48443IPR000324VitD_rcptVitamin D receptor
6258RXRG_HUMANP48443IPR013629Znf-C4_CZinc finger, C4-type, C-terminal

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