Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6263
Official Symbol:RYR3
Other Aliases:-
See related:HGNC:10485|MIM:180903|HPRD:01620
Chromosome:15
Location:15q14-q15
Gene Description:ryanodine receptor 3
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:HOT0012
ORGANISM:human
Entrez Gene ID:6263
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:HOT0305
ORGANISM:human
Entrez Gene ID:6263
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20192CBCerebellum3.261961936950683.68909239768982
20192CTXCerebral cortex0.9893503785133361.04669630527496
20192HIPHippocampal region1.645127296447752.16585826873779
20192HPFHippocampal formation1.268236756324771.72675788402557
20192HYHypothalamus0.376658439636230.374746173620224
20192LSXLateral septal complex0.5612823963165280.409751087427139
20192MBMidbrain0.3114742338657380.410414904356003
20192MYMedulla1.018002748489381.37151336669922
20192OLFOlfactory bulb1.010579109191891.17698073387146
20192PPons0.4703423380851750.574552237987518
20192PALPallidum0.225033253431320.680214643478394
20192RHPRetrohippocampal region0.5202560424804690.795973837375641
20192sAMYStriatum-like amygdalar nuclei0.4343969225883480.65416008234024
20192STRStriatum0.5200728178024290.544111967086792
20192STRdStriatum dorsal region0.5667799711227420.627277135848999
20192STRvStriatum ventral region0.4758127927780150.388578861951828
20192THThalamus0.545526862144470.55139148235321
KARG Evidence 3
KARG ID:HOT0012
Entrez Gene ID:6263
RefSeq ID:NM_001036
Position Information:+, Intron, 0bp
Linkage Marker:rs0735612
Evidence Type:ASSOCIATION GENOME SCANNING
Evidence Name:PUBMED
Evidence ID:16091475
Addiction Drug:POLYSUBSTANCE
Addiction Drug Detail:POLYSUBSTANCE ABUSE
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6263GO:0004872IEAFunctionreceptor activity
6263GO:0005219IEAFunctionryanodine-sensitive calcium-release channel activity
6263GO:0005509IEAFunctioncalcium ion binding
6263GO:0005624NRComponentmembrane fraction
6263GO:0005887NRComponentintegral to plasma membrane
6263GO:0006812IEAProcesscation transport
6263GO:0006816TASProcesscalcium ion transport
6263GO:0006874IEAProcesscalcium ion homeostasis
6263GO:0015278TASFunctioncalcium-release channel activity
6263GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6263RYR3_HUMANQ15413IPR000194ATPase_a_b_nl-bdATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding
6263RYR3_HUMANQ15413IPR000699Ca-rel_channelIntracellular calcium-release channel
6263RYR3_HUMANQ15413IPR001682Ca/Na_poreCa2+/Na+ channel, pore region
6263RYR3_HUMANQ15413IPR013567EF_hand_assoc_2EF hand associated, type-2
6263RYR3_HUMANQ15413IPR002048EF_hand_Ca_bdCalcium-binding EF-hand
6263RYR3_HUMANQ15413IPR000493InsP3_rcpt_bdInositol 1,4,5-trisphosphate-binding protein receptor
6263RYR3_HUMANQ15413IPR005821Ion_transIon transport
6263RYR3_HUMANQ15413IPR013621Ion_trans_NIon transport N-terminal
6263RYR3_HUMANQ15413IPR003608MIRMIR
6263RYR3_HUMANQ15413IPR013684Miro-likeMiro-like
6263RYR3_HUMANQ15413IPR013623NADPH_OxNADPH oxidase Respiratory burst
6263RYR3_HUMANQ15413IPR013662RIH_assocRyR and IP3R Homology associated
6263RYR3_HUMANQ15413IPR003032Ryanodine_rcptRyanodine receptor Ryr
6263RYR3_HUMANQ15413IPR009460Ryanrecept_TM4-6Ryanodine Receptor TM 4-6
6263RYR3_HUMANQ15413IPR013333Ryan_recept_NRyanodine receptor, N terminal
6263RYR3_HUMANQ15413IPR003877SPRY_rcptSPla/RYanodine receptor SPRY

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