Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:627
Official Symbol:BDNF
Other Aliases:MGC34632
See related:HGNC:1033|MIM:113505|HPRD:00214
Chromosome:11
Location:11p13
Gene Description:brain-derived neurotrophic factor
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0048
ORGANISM:human
Entrez Gene ID:627
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12064
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0448
ORGANISM:human
Entrez Gene ID:627
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24225
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIL0139
ORGANISM:human
Entrez Gene ID:627
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15547445
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 4
KARG ID:EVIL0202
ORGANISM:human
Entrez Gene ID:627
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:16152573
Addiction Drug:NICOTINE
Addiction Drug Detail:NICOTINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 5
KARG ID:EVID0001
ORGANISM:human
Entrez Gene ID:627
Evidence Type:Database Annotations
Evidence ID Type:OMIM
Evidence ID:MIM:113505
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12064CBCerebellum2.122836589813232.61799200375875
12064CTXCerebral cortex31.102561950683628.0205586751302
12064HIPHippocampal region28.53247070312558.5552393595378
12064HPFHippocampal formation23.999835968017640.7163683573405
12064HYHypothalamus12.87872823079439.54991658528646
12064LSXLateral septal complex1.155906399091081.74744447072347
12064MBMidbrain8.933083534240726.90491898854574
12064MYMedulla4.40617624918623.74574359258016
12064OLFOlfactory bulb21.732098261515320.7657025655111
12064PPons7.566090901692716.50408442815145
12064PALPallidum2.426314433415731.82830985387166
12064RHPRetrohippocampal region16.614210128784214.7591133117676
12064sAMYStriatum-like amygdalar nuclei6.288703600565594.80986213684082
12064STRStriatum2.09583465258281.85489046573639
12064STRdStriatum dorsal region1.86922635634741.75590479373932
12064STRvStriatum ventral region1.143423000971480.839889168739319
12064THThalamus5.597140709559125.05668910344442
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
627GO:0007399TASProcessnervous system development
627GO:0008083IEAFunctiongrowth factor activity
627GO:0008083TASFunctiongrowth factor activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_001700.14846NP_000594.1nitric oxide synthase 3 (endothelial cell)HPRD01224
NP_001700.14846NP_000594.1nitric oxide synthase 3 (endothelial cell)HPRD00214
NP_001700.14684NP_000606.1neural cell adhesion molecule 1 isoform 1HPRD00214
NP_001700.14684NP_000606.1neural cell adhesion molecule 1 isoform 1HPRD00301
NP_001700.14908NP_002518.1neurotrophin 3 precursorHPRD00214
NP_001700.14908NP_002518.1neurotrophin 3 precursorHPRD01219
NP_001700.14909NP_006170.1neurotrophin 5 preproproteinHPRD00214
NP_001700.14909NP_006170.1neurotrophin 5 preproproteinHPRD01220
NP_001700.14915NP_006171.2neurotrophic tyrosine kinase, receptor, type 2 isoform a precursorHPRD02712
NP_001700.14915NP_006171.2neurotrophic tyrosine kinase, receptor, type 2 isoform a precursorHPRD00214
NP_001700.22099NP_000116.1estrogen receptor 1HPRD00214
NP_001700.24846NP_000594.1nitric oxide synthase 3 (endothelial cell)HPRD00214
NP_001700.24684NP_000606.1neural cell adhesion molecule 1 isoform 1HPRD00214
NP_001700.24908NP_002518.1neurotrophin 3 precursorHPRD00214
NP_001700.24909NP_006170.1neurotrophin 5 preproproteinHPRD00214
NP_001700.24915NP_006171.2neurotrophic tyrosine kinase, receptor, type 2 isoform a precursorHPRD00214
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
627BDNF_HUMANP23560IPR002072NGFNerve growth factor

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