Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6310
Official Symbol:ATXN1
Other Aliases:ATX1|D6S504E|SCA1
See related:HGNC:10548|MIM:601556|HPRD:03333
Chromosome:6
Location:6p23
Gene Description:ataxin 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0375
ORGANISM:human
Entrez Gene ID:6310
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.3 :: 1.1 :: 1.2 :: -1.1 :: -1.2 :: -1.5
KARG Evidence 2
KARG ID:EVIM0443
ORGANISM:human
Entrez Gene ID:6310
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.2 :: -1.4 :: -1.5 :: -1.7 :: -1
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20238CBCerebellum14.767072677612312.4194235801697
20238CTXCerebral cortex71.307985305786148.8604736328125
20238HIPHippocampal region61.798910140991261.6487407684326
20238HPFHippocampal formation57.77572822570853.1795444488525
20238HYHypothalamus11.77927255630497.34079909324646
20238LSXLateral septal complex43.307264328002926.6320781707764
20238MBMidbrain15.679627895355211.0359668731689
20238MYMedulla17.220214366912813.7642502784729
20238OLFOlfactory bulb64.907051086425840.0876922607422
20238PPons12.42383670806889.59318113327026
20238PALPallidum22.811101913452115.7152981758118
20238RHPRetrohippocampal region51.749797821044941.0811595916748
20238sAMYStriatum-like amygdalar nuclei33.221063613891618.8020820617676
20238STRStriatum74.461921691894547.2170829772949
20238STRdStriatum dorsal region85.047107696533256.2847080230713
20238STRvStriatum ventral region74.557029724121142.7813034057617
20238THThalamus66.416568756103558.5510597229004
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6310GO:0003723IEAFunctionRNA binding
6310GO:0005634TASComponentnucleus
6310GO:0005737TASComponentcytoplasm
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7874NP_003461.1ubiquitin specific protease 7 (herpes virus-associated)HPRD03950
-8161NP_004636.1coilinHPRD02605
-8125NP_006296.1acidic (leucine-rich) nuclear phosphoprotein 32 family, member AHPRD09014
-56893NP_064516.1ataxin-1 ubiquitin-like interacting proteinHPRD05670
NP_000323.1--LANPHPRD03333
NP_000323.18125-HLA DR associated protein IHPRD03333
NP_000323.156893-Ataxin 1 ubiquitin like interacting proteinHPRD03333
NP_000323.17874-Ubiquitin specific protease 7HPRD03333
NP_000323.18161-CoilinHPRD03333
NP_000323.110084NP_005701.1polyglutamine binding protein 1 isoform 1HPRD03333
NP_000323.110084NP_005701.1polyglutamine binding protein 1 isoform 1HPRD02354
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6310ATX1_HUMANP54253IPR013723Ataxin-1_HBP1Ataxin-1 and HBP1 module (AXH)

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