Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6347
Official Symbol:CCL2
Other Aliases:GDCF-2|GDCF-2 HC11|HC11|HSMCR30|MCAF|MCP-1|MCP1|MGC9434|SCYA2|SMC-CF
See related:HGNC:10618|MIM:158105|HPRD:01149
Chromosome:17
Location:17q11.2-q12
Gene Description:chemokine (C-C motif) ligand 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0216
ORGANISM:human
Entrez Gene ID:6347
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Downregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6347GO:0004672TASFunctionprotein kinase activity
6347GO:0005615TASComponentextracellular space
6347GO:0006468TASProcessprotein amino acid phosphorylation
6347GO:0006874TASProcesscalcium ion homeostasis
6347GO:0006916IDAProcessanti-apoptosis
6347GO:0006935TASProcesschemotaxis
6347GO:0006954IEAProcessinflammatory response
6347GO:0006959TASProcesshumoral immune response
6347GO:0007155TASProcesscell adhesion
6347GO:0007187TASProcessG-protein signaling, coupled to cyclic nucleotide second messenger
6347GO:0007259TASProcessJAK-STAT cascade
6347GO:0007267NRProcesscell-cell signaling
6347GO:0008009TASFunctionchemokine activity
6347GO:0009618TASProcessresponse to pathogenic bacteria
6347GO:0009887TASProcessorgan morphogenesis
6347GO:0016020IEAComponentmembrane
6347GO:0019079TASProcessviral genome replication
6347GO:0050896IEAProcessresponse to stimulus
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002973.16347NP_002973.1small inducible cytokine A2 precursorHPRD01149
NP_002973.1155871NP_057853.1Tat--
NP_002973.1155871NP_057853.1Tat--
NP_002973.1155871NP_057853.1Tat--
NP_002973.1155871NP_057853.1Tat--
NP_002973.1155871NP_057853.1Tat--
NP_002973.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6347CCL2_HUMANP13500IPR000827CC_chemkine_smlSmall chemokine, C-C
6347CCL2_HUMANP13500IPR001811Chemokine_IL8Small chemokine, interleukin-8-like
6347CCL2_HUMANP13500IPR008097FractalkineFractalkine/neurotactin

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