Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:637
Official Symbol:BID
Other Aliases:MGC15319|MGC42355
See related:HGNC:1050|MIM:601997|HPRD:03590
Chromosome:22
Location:22q11.1
Gene Description:BH3 interacting domain death agonist
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0199
ORGANISM:human
Entrez Gene ID:637
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12122
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12122CBCerebellum7.916269779205329.08469009399414
12122CTXCerebral cortex20.425553321838414.929069519043
12122HIPHippocampal region26.21856021881135.4999923706055
12122HPFHippocampal formation29.252776145935134.3590021133423
12122HYHypothalamus12.856456279754610.5629601478577
12122LSXLateral septal complex10.12555313110357.66976404190063
12122MBMidbrain10.455286979675310.0733420848846
12122MYMedulla20.988036632537824.6348390579224
12122OLFOlfactory bulb36.013753890991236.1723346710205
12122PPons18.882400989532520.4295692443848
12122PALPallidum16.053157806396514.8453440666199
12122RHPRetrohippocampal region35.80564308166534.1502094268799
12122sAMYStriatum-like amygdalar nuclei13.534594058990510.0393915176392
12122STRStriatum10.02339625358587.52836298942566
12122STRdStriatum dorsal region7.813392400741585.94611608982086
12122STRvStriatum ventral region15.714210033416710.9928753376007
12122THThalamus7.225430011749276.95010256767273
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
637GO:0005123TASFunctiondeath receptor binding
637GO:0005515IPIFunctionprotein binding
637GO:0005624TASComponentmembrane fraction
637GO:0005739TASComponentmitochondrion
637GO:0005829TASComponentcytosol
637GO:0008625TASProcessinduction of apoptosis via death domain receptors
637GO:0008637TASProcessapoptotic mitochondrial changes
637GO:0043065IEAProcesspositive regulation of apoptosis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-835NP_116764.2caspase 2 isoform 1 preproproteinHPRD02800
NP_001187.1--tBidHPRD03590
NP_001187.1835-Caspase 2HPRD03590
NP_001187.17529-14-3-3 BetaHPRD03590
NP_001187.1637NP_001187.1BH3 interacting domain death agonist isoform 2HPRD03590
NP_001187.1646NP_001708.2basonuclin 1BIND209453
NP_001187.1823NP_005177.2calpain 1, large subunitHPRD00253
NP_001187.1823NP_005177.2calpain 1, large subunitHPRD03590
NP_001187.123241NP_056012.1phosphofurin acidic cluster sorting protein 2BIND215929
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
637IPR010479BIDBH3 interacting
637BID_HUMANP55957IPR000712Bcl2_BHApoptosis regulator Bcl-2, BH
637BID_HUMANP55957IPR010479BIDBH3 interacting

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