Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6376
Official Symbol:CX3CL1
Other Aliases:ABCD-3|C3Xkine|CXC3|CXC3C|NTN|NTT|SCYD1|fractalkine|neurotactin
See related:HGNC:10647|MIM:601880|HPRD:03529
Chromosome:16
Location:16q13
Gene Description:chemokine (C-X3-C motif) ligand 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0537
ORGANISM:human
Entrez Gene ID:6376
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:89808
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20312CBCerebellum75.17499160766677.1313533782959
20312CTXCerebral cortex100.0100.0
20312HIPHippocampal region100.0100.0
20312HPFHippocampal formation100.0100.0
20312HYHypothalamus100.0100.0
20312LSXLateral septal complex100.0100.0
20312MBMidbrain100.0100.0
20312MYMedulla97.2025985717773100.0
20312OLFOlfactory bulb100.0100.0
20312PPons97.2313842773438100.0
20312PALPallidum100.0100.0
20312RHPRetrohippocampal region100.0100.0
20312sAMYStriatum-like amygdalar nuclei100.0100.0
20312STRStriatum100.0100.0
20312STRdStriatum dorsal region100.0100.0
20312STRvStriatum ventral region100.0100.0
20312THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6376GO:0005615IEAComponentextracellular space
6376GO:0006955TASProcessimmune response
6376GO:0007155IEAProcesscell adhesion
6376GO:0008009TASFunctionchemokine activity
6376GO:0009986IDAComponentcell surface
6376GO:0016020IEAComponentmembrane
6376GO:0016021IDAComponentintegral to membrane
6376GO:0019221TASProcesscytokine and chemokine mediated signaling pathway
6376GO:0030595TASProcessimmune cell chemotaxis
6376GO:0050729IEPProcesspositive regulation of inflammatory response
6376GO:0050902TASProcessleukocyte adhesive activation
6376GO:0051041IDAProcesspositive regulation of calcium-independent cell-cell adhesion
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002987.16376NP_002987.1chemokine (C-X3-C motif) ligand 1HPRD03529
NP_002987.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6376X3CL1_HUMANP78423IPR001811Chemokine_IL8Small chemokine, interleukin-8-like
6376X3CL1_HUMANP78423IPR008097FractalkineFractalkine/neurotactin

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