Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6383
Official Symbol:SDC2
Other Aliases:HSPG|HSPG1|SYND2
See related:HGNC:10659|MIM:142460|HPRD:00803
Chromosome:8
Location:8q22-q23
Gene Description:syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0292
ORGANISM:human
Entrez Gene ID:6383
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Upregulated
Fold Change:0.72
KARG Evidence 2
KARG ID:EVIM0387
ORGANISM:human
Entrez Gene ID:6383
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.9 :: -1.3 :: -1.4 :: -1 :: -1.6
KARG Evidence 3
KARG ID:EVIM0455
ORGANISM:human
Entrez Gene ID:6383
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.6 :: -1.2 :: -1.2 :: 1.2 :: 1.2
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
15529CBCerebellum4.987185716629036.11173868179321
15529CTXCerebral cortex3.801773905754093.3104156255722
15529HIPHippocampal region2.670783400535583.00368416309357
15529HPFHippocampal formation2.658530473709112.81110441684723
15529HYHypothalamus21.818655014038122.103006362915
15529LSXLateral septal complex12.019695758819610.167163848877
15529MBMidbrain9.4534976482391412.3224296569824
15529MYMedulla7.020606994628919.62329792976379
15529OLFOlfactory bulb11.191431999206510.0977149009705
15529PPons11.593978404998813.8633494377136
15529PALPallidum9.111822366714488.51339626312256
15529RHPRetrohippocampal region2.602886915206912.26609468460083
15529sAMYStriatum-like amygdalar nuclei18.61446285247816.2478733062744
15529STRStriatum10.73020219802869.63599467277527
15529STRdStriatum dorsal region6.642727375030526.65024042129517
15529STRvStriatum ventral region18.277618408203114.0614943504333
15529THThalamus8.023817777633678.52831363677979
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6383GO:0000004NDProcessbiological process unknown
6383GO:0005554NDFunctionmolecular function unknown
6383GO:0005887NASComponentintegral to plasma membrane
6383GO:0008092IEAFunctioncytoskeletal protein binding
6383GO:0016020IEAComponentmembrane
6383GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6678NP_003109.1secreted protein, acidic, cysteine-rich (osteonectin)HPRD01631
-7430NP_003370.2villin 2HPRD00475
-8573NP_003679.1calcium/calmodulin-dependent serine protein kinase (MAGUK family)HPRD02164
-6386NP_005616.1syndecan binding protein (syntenin)HPRD03741
NP_002989.1--SynbindinHPRD00803
NP_002989.16678-OsteonectinHPRD00803
NP_002989.16386-SynteninHPRD00803
NP_002989.18573-CASKHPRD00803
NP_002989.17430-EzrinHPRD00803
NP_002989.1155871NP_057853.1Tat--
NP_002989.1155871NP_057853.1Tat--
NP_002989.251399NP_057230.1trafficking protein particle complex 4HPRD18220
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6383SDC2_HUMANP34741IPR001050SyndecanSyndecan

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