Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6387
Official Symbol:CXCL12
Other Aliases:PBSF|SCYB12|SDF-1a|SDF-1b|SDF1|SDF1A|SDF1B|TLSF-a|TLSF-b|TPAR1|chemokine
See related:HGNC:10672|MIM:600835|HPRD:02904
Chromosome:10
Location:10q11.1
Gene Description:chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0212
ORGANISM:human
Entrez Gene ID:6387
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Downregulated
Fold Change:At least 2-folds difference
KARG Evidence 2
KARG ID:EVIM0304
ORGANISM:human
Entrez Gene ID:6387
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.51
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20315CBCerebellum3.26433014869693.90560615062714
20315CTXCerebral cortex4.444412231445314.04505586624146
20315HIPHippocampal region15.43989324569710.203200340271
20315HPFHippocampal formation10.88004922866827.05209040641785
20315HYHypothalamus0.7290274202823640.71727192401886
20315LSXLateral septal complex2.250925958156592.05125540494919
20315MBMidbrain1.739805757999422.08268493413925
20315MYMedulla2.344980001449582.67239880561829
20315OLFOlfactory bulb3.050315618515012.55852520465851
20315PPons2.37721043825152.48492741584778
20315PALPallidum0.8485005795955661.13398370146751
20315RHPRetrohippocampal region3.866393923759463.04897439479828
20315sAMYStriatum-like amygdalar nuclei3.48962283134463.16506433486938
20315STRStriatum1.755894839763641.69409072399139
20315STRdStriatum dorsal region1.330233424901961.33156707882881
20315STRvStriatum ventral region1.225963413715361.03979143500328
20315THThalamus2.879392683506012.55140483379364
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6387GO:0005576IEAComponentextracellular region
6387GO:0005615IEAComponentextracellular space
6387GO:0006874TASProcesscalcium ion homeostasis
6387GO:0006935TASProcesschemotaxis
6387GO:0006954NRProcessinflammatory response
6387GO:0006955IEAProcessimmune response
6387GO:0007155TASProcesscell adhesion
6387GO:0007165TASProcesssignal transduction
6387GO:0007186TASProcessG-protein coupled receptor protein signaling pathway
6387GO:0007267NRProcesscell-cell signaling
6387GO:0008009IEAFunctionchemokine activity
6387GO:0008009TASFunctionchemokine activity
6387GO:0008015TASProcesscirculation
6387GO:0008064TASProcessregulation of actin polymerization and/or depolymerization
6387GO:0008083IEAFunctiongrowth factor activity
6387GO:0009615TASProcessresponse to virus
6387GO:0050896IEAProcessresponse to stimulus
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7852NP_003458.1chemokine (C-X-C motif) receptor 4 isoform bHPRD01217
NP_000600.17852-CXCR4HPRD02904
NP_000600.17852-Chemokine, CXC motif, receptor 4HPRD02904
NP_000600.16387NP_000600.1chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) isoform betaHPRD02904
NP_000600.1155871NP_057853.1Tat--
NP_000600.1155871NP_057853.1Tat--
NP_000600.1155871NP_057853.1Tat--
NP_000600.1155871NP_057853.1Tat--
NP_000600.1155871NP_057853.1Tat--
NP_954637.17852NP_003458.1chemokine (C-X-C motif) receptor 4 isoform bBIND144680
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6387IPR002473C-X-C/Interlkn_8Small chemokine, C-X-C/Interleukin 8
6387IPR001811Chemokine_IL8Small chemokine, interleukin-8-like
6387IPR001089CXC_chmkine_smllSmall chemokine, C-X-C
6387SDF1_HUMANP48061IPR002473C-X-C/Interlkn_8Small chemokine, C-X-C/Interleukin 8
6387SDF1_HUMANP48061IPR001811Chemokine_IL8Small chemokine, interleukin-8-like
6387SDF1_HUMANP48061IPR001089CXC_chmkine_smllSmall chemokine, C-X-C

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