Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6422
Official Symbol:SFRP1
Other Aliases:FRP|FRP-1|FRP1|FrzA|SARP2
See related:HGNC:10776|MIM:604156|HPRD:09165
Chromosome:8
Location:8p12-p11.1
Gene Description:secreted frizzled-related protein 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0865
ORGANISM:human
Entrez Gene ID:6422
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.5 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20377CBCerebellum55.255437850952134.951376914978
20377CTXCerebral cortex48.527332305908225.9243388175964
20377HIPHippocampal region32.958503723144516.0564613342285
20377HPFHippocampal formation37.682525634765621.087818145752
20377HYHypothalamus15.49177265167248.80222404003143
20377LSXLateral septal complex17.67815065383919.36105036735535
20377MBMidbrain17.717590808868413.880669593811
20377MYMedulla46.087074279785236.247239112854
20377OLFOlfactory bulb59.60815429687528.6080441474915
20377PPons35.740564346313530.4285001754761
20377PALPallidum18.721891880035410.4266167879105
20377RHPRetrohippocampal region44.453397750854526.7296237945557
20377sAMYStriatum-like amygdalar nuclei27.973622322082514.1893649101257
20377STRStriatum23.522597789764411.8121340274811
20377STRdStriatum dorsal region18.47144842147839.62989735603333
20377STRvStriatum ventral region38.524171829223616.9675898551941
20377THThalamus11.00069403648386.02053391933441
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6422GO:0016055IEAProcessWnt receptor signaling pathway
6422GO:0030154IEAProcesscell differentiation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_003003.27472NP_003382.1wingless-type MMTV integration site family member 2 precursorHPRD09165
NP_003003.27472NP_003382.1wingless-type MMTV integration site family member 2 precursorHPRD00999
NP_003003.28323NP_003497.1frizzled 6HPRD09165
NP_003003.28323NP_003497.1frizzled 6HPRD04559
NP_003003.27471NP_005421.1wingless-type MMTV integration site family, member 1 precursorHPRD01276
NP_003003.27471NP_005421.1wingless-type MMTV integration site family, member 1 precursorHPRD09165
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6422SFRP1_HUMANQ8N474IPR000024Fz_domainFrizzled CRD region
6422SFRP1_HUMANQ8N474IPR001134Netrin_CNetrin, C-terminal

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.