Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6443
Official Symbol:SGCB
Other Aliases:A3b|LGMD2E|SGC
See related:HGNC:10806|MIM:600900|HPRD:02942
Chromosome:4
Location:4q12
Gene Description:sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0119
ORGANISM:human
Entrez Gene ID:6443
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.75 :: 1.39 :: 0.29 :: 1.00 :: -1.30 :: -1.25 :: -1.48
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
24051CBCerebellum26.442033767700237.518970489502
24051CTXCerebral cortex64.92688751220751.2972183227539
24051HIPHippocampal region44.340377807617272.3441925048828
24051HPFHippocampal formation47.912479400634861.4735260009766
24051HYHypothalamus21.259769439697319.1072673797607
24051LSXLateral septal complex22.068220138549817.7003746032715
24051MBMidbrain32.506191253662132.749584197998
24051MYMedulla44.894168853759853.6519927978516
24051OLFOlfactory bulb40.437191009521533.710391998291
24051PPons32.203712463378938.9151725769043
24051PALPallidum26.816202163696327.8923988342285
24051RHPRetrohippocampal region54.183872222900448.4942970275879
24051sAMYStriatum-like amygdalar nuclei31.412574768066423.6324882507324
24051STRStriatum31.820569992065424.9916343688965
24051STRdStriatum dorsal region31.766527175903325.5428981781006
24051STRvStriatum ventral region37.128391265869127.0563716888428
24051THThalamus51.799266815185549.1782112121582
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6443GO:0005856IEAComponentcytoskeleton
6443GO:0005887TASComponentintegral to plasma membrane
6443GO:0007010IEAProcesscytoskeleton organization and biogenesis
6443GO:0007517TASProcessmuscle development
6443GO:0016012TASComponentsarcoglycan complex
6443GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6444NP_000328.2delta-sarcoglycan isoform 1HPRD03246
-137868NP_631906.1sarcoglycan zetaHPRD12165
NP_000223.16444-Sarcoglycan, deltaHPRD02942
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6443SGCB_HUMANQ16585IPR006875SarcoglycanSarcoglycan complex subunit protein

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