Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6446
Official Symbol:SGK
Other Aliases:SGK1
See related:HGNC:10810|MIM:602958|HPRD:04264
Chromosome:6
Location:6q23
Gene Description:serum/glucocorticoid regulated kinase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0234
ORGANISM:human
Entrez Gene ID:6446
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:20393
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0443
ORGANISM:human
Entrez Gene ID:6446
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:29517
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20393CBCerebellum17.283466339111313.8742256164551
20393CTXCerebral cortex52.131439208984423.9431972503662
20393HIPHippocampal region37.287364959716831.8032493591309
20393HPFHippocampal formation34.441608428955123.4302959442139
20393HYHypothalamus31.070468902587911.2559337615967
20393LSXLateral septal complex18.24166679382326.70290517807007
20393MBMidbrain38.265399932861316.739185333252
20393MYMedulla46.958118438720723.6209659576416
20393OLFOlfactory bulb34.678691864013716.3298759460449
20393PPons45.293972015380918.7779979705811
20393PALPallidum29.671440124511711.381178855896
20393RHPRetrohippocampal region30.027320861816412.1162366867065
20393sAMYStriatum-like amygdalar nuclei18.38269996643076.49305725097656
20393STRStriatum47.075428009033218.3674240112305
20393STRdStriatum dorsal region58.524322509765622.8046340942383
20393STRvStriatum ventral region41.169860839843815.5725555419922
20393THThalamus42.089588165283221.5780830383301
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6446GO:0000166IEAFunctionnucleotide binding
6446GO:0004674IEAFunctionprotein serine/threonine kinase activity
6446GO:0004674TASFunctionprotein serine/threonine kinase activity
6446GO:0005524IEAFunctionATP binding
6446GO:0005634IEAComponentnucleus
6446GO:0006468IEAProcessprotein amino acid phosphorylation
6446GO:0006468TASProcessprotein amino acid phosphorylation
6446GO:0006814TASProcesssodium ion transport
6446GO:0006915IEAProcessapoptosis
6446GO:0006950TASProcessresponse to stress
6446GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-23327NP_056092.2ubiquitin-protein ligase NEDD4-likeHPRD05903
NP_005618.2--CaMKKHPRD04264
NP_005618.223327-Ubiquitin protein ligase NEDD4 likeHPRD04264
NP_005618.29351NP_004776.1solute carrier family 9 isoform 3 regulator 2HPRD05946
NP_005618.29351NP_004776.1solute carrier family 9 isoform 3 regulator 2HPRD04264
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6446SGK1_HUMANO00141IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
6446SGK1_HUMANO00141IPR000961Pkinase_CProtein kinase, C-terminal
6446SGK1_HUMANO00141IPR000719Prot_kinaseProtein kinase
6446SGK1_HUMANO00141IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
6446SGK1_HUMANO00141IPR001245Tyr_pkinaseTyrosine protein kinase
6446SGK1_HUMANO00141IPR013695WAKWall-associated kinase

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