Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6506
Official Symbol:SLC1A2
Other Aliases:EAAT2|GLT-1
See related:HGNC:10940|MIM:600300|HPRD:02625
Chromosome:11
Location:11p13-p12
Gene Description:solute carrier family 1 (glial high affinity glutamate transporter), member 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0943
ORGANISM:human
Entrez Gene ID:6506
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:1.1 :: -1.9 :: -5.1 :: -1.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20511CBCerebellum49.4011974334717100.0
20511CTXCerebral cortex100.0100.0
20511HIPHippocampal region100.0100.0
20511HPFHippocampal formation100.0100.0
20511HYHypothalamus74.879629135131882.1763114929199
20511LSXLateral septal complex100.0100.0
20511MBMidbrain83.963653564453187.8873291015625
20511MYMedulla89.79133224487395.9768829345703
20511OLFOlfactory bulb100.0100.0
20511PPons91.780780792236396.6719627380371
20511PALPallidum69.999446868896577.713077545166
20511RHPRetrohippocampal region100.0100.0
20511sAMYStriatum-like amygdalar nuclei92.833332061767697.2266426086426
20511STRStriatum97.0113067626953100.0
20511STRdStriatum dorsal region94.7338638305664100.0
20511STRvStriatum ventral region95.376873016357498.9943504333496
20511THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6506GO:0005313TASFunctionL-glutamate transporter activity
6506GO:0005624TASComponentmembrane fraction
6506GO:0006810IEAProcesstransport
6506GO:0006835IEAProcessdicarboxylic acid transport
6506GO:0007268TASProcesssynaptic transmission
6506GO:0015293IEAFunctionsymporter activity
6506GO:0015813TASProcessL-glutamate transport
6506GO:0016020IEAComponentmembrane
6506GO:0016021IEAComponentintegral to membrane
6506GO:0017153IEAFunctionsodium:dicarboxylate symporter activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NC_000011.8---BIND145606
NP_004162.1--AjubaHPRD02625
NP_004162.184962NP_116265.1jub, ajuba homolog isoform 1HPRD16426
NP_004162.2---BIND182187
NP_004162.26506NP_004162.2solute carrier family 1, member 2BIND182186
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6506EAA2_HUMANP43004IPR001991Na/diCO_symportSodium:dicarboxylate symporter

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