Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:65125
Official Symbol:WNK1
Other Aliases:KDP|KIAA0344|PHA2C|PRKWNK1
See related:HGNC:14540|MIM:605232|HPRD:05570
Chromosome:12
Location:12p13.3
Gene Description:WNK lysine deficient protein kinase 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0329
ORGANISM:human
Entrez Gene ID:65125
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.67
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
232341CBCerebellum65.9905548095703100.0
232341CTXCerebral cortex100.095.8875503540039
232341HIPHippocampal region80.3131561279297100.0
232341HPFHippocampal formation87.4309921264648100.0
232341HYHypothalamus79.221069335937567.1087875366211
232341LSXLateral septal complex77.053199768066457.2221069335938
232341MBMidbrain92.680854797363393.5341873168945
232341MYMedulla100.0100.0
232341OLFOlfactory bulb100.0100.0
232341PPons100.0100.0
232341PALPallidum82.983665466308678.3002853393555
232341RHPRetrohippocampal region99.510887145996183.8073883056641
232341sAMYStriatum-like amygdalar nuclei71.89954376220753.8248481750488
232341STRStriatum96.652893066406275.200309753418
232341STRdStriatum dorsal region100.084.0344314575195
232341STRvStriatum ventral region95.102005004882868.9745407104492
232341THThalamus100.098.4309463500977
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
65125GO:0000166IEAFunctionnucleotide binding
65125GO:0004674IDAFunctionprotein serine/threonine kinase activity
65125GO:0004860IEAFunctionprotein kinase inhibitor activity
65125GO:0005515IPIFunctionprotein binding
65125GO:0005524IDAFunctionATP binding
65125GO:0005737IDAComponentcytoplasm
65125GO:0006468IDAProcessprotein amino acid phosphorylation
65125GO:0006811ISSProcession transport
65125GO:0007243IDAProcessprotein kinase cascade
65125GO:0016740IEAFunctiontransferase activity
65125GO:0050794ISSProcessregulation of cellular process
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
65125WNK1_HUMANQ9H4A3IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
65125WNK1_HUMANQ9H4A3IPR003072NOR1_rcptOrphan nuclear receptor, NOR1 type
65125WNK1_HUMANQ9H4A3IPR000719Prot_kinaseProtein kinase
65125WNK1_HUMANQ9H4A3IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
65125WNK1_HUMANQ9H4A3IPR001245Tyr_pkinaseTyrosine protein kinase
65125WNK1_HUMANQ9H4A3IPR013695WAKWall-associated kinase

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