Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6520
Official Symbol:SLC3A2
Other Aliases:4F2|4F2HC|4T2HC|CD98|CD98HC|MDU1|NACAE
See related:HGNC:11026|MIM:158070|HPRD:01148
Chromosome:11
Location:11q13
Gene Description:solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0331
ORGANISM:human
Entrez Gene ID:6520
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:0.76
KARG Evidence 2
KARG ID:QTL0248
ORGANISM:human
Entrez Gene ID:6520
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17254CBCerebellum33.732513427734456.1876983642578
17254CTXCerebral cortex100.097.0824127197266
17254HIPHippocampal region50.071376800537173.3753280639648
17254HPFHippocampal formation67.899734497070382.4700393676758
17254HYHypothalamus22.522348403930721.2704467773438
17254LSXLateral septal complex24.316295623779320.051929473877
17254MBMidbrain24.763565063476626.5127086639404
17254MYMedulla45.43785858154355.2794761657715
17254OLFOlfactory bulb77.746658325195369.4617691040039
17254PPons37.644428253173846.8920555114746
17254PALPallidum26.565677642822326.8293418884277
17254RHPRetrohippocampal region100.099.0442352294922
17254sAMYStriatum-like amygdalar nuclei35.446857452392632.7995109558105
17254STRStriatum26.330039978027323.357234954834
17254STRdStriatum dorsal region23.934949874877922.173511505127
17254STRvStriatum ventral region27.13358116149920.0489253997803
17254THThalamus62.975914001464866.39208984375
KARG Evidence 3
KARG ID:QTL0248
Trait:METH responses for body temperature
Peak:0
Peak Marker:Gnblps1
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:8987796
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6520GO:0003824IEAFunctioncatalytic activity
6520GO:0004556IEAFunctionalpha-amylase activity
6520GO:0005432TASFunctioncalcium:sodium antiporter activity
6520GO:0005975IEAProcesscarbohydrate metabolism
6520GO:0006816NASProcesscalcium ion transport
6520GO:0006865TASProcessamino acid transport
6520GO:0009986IEPComponentcell surface
6520GO:0016020IEAComponentmembrane
6520GO:0016021NASComponentintegral to membrane
6520GO:0016049NASProcesscell growth
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002385.28140NP_003477.3solute carrier family 7 (cationic amino acid transporter, y+ system), member 5HPRD01148
NP_002385.28140NP_003477.3solute carrier family 7 (cationic amino acid transporter, y+ system), member 5HPRD02552
NP_002385.29056NP_003973.2solute carrier family 7 (cationic amino acid transporter, y+ system), member 7HPRD01148
NP_002385.29056NP_003973.2solute carrier family 7 (cationic amino acid transporter, y+ system), member 7HPRD04667
NP_002385.223428NP_036376.2solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 isoform aHPRD11971
NP_002385.223657NP_055146.1solute carrier family 7, (cationic amino acid transporter, y+ system) member 11HPRD09720
NP_002385.256301NP_062823.1solute carrier family 7, member 10HPRD12137
NP_002385.279850NP_079068.1family with sequence similarity 57, member AHPRD13096
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
65204F2_HUMANP08195IPR006047Alpha_amyl_catAlpha amylase, catalytic region

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