Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6529
Official Symbol:SLC6A1
Other Aliases:GABATHG|GABATR|GAT1
See related:HGNC:11042|MIM:137165|HPRD:00664
Chromosome:3
Location:3p25-p24
Gene Description:solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0051
ORGANISM:human
Entrez Gene ID:6529
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:232333
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0457
ORGANISM:human
Entrez Gene ID:6529
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:79212
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
232333CBCerebellum90.120559692382892.6563606262207
232333CTXCerebral cortex35.168807029724141.5779619216919
232333HIPHippocampal region29.109177589416551.1603450775146
232333HPFHippocampal formation36.485877990722752.8248310089111
232333HYHypothalamus19.010686397552514.9392704963684
232333LSXLateral septal complex36.815370559692431.0494136810303
232333MBMidbrain30.261229515075727.0009121894836
232333MYMedulla17.878645420074514.9016470909119
232333OLFOlfactory bulb51.257570266723646.727180480957
232333PPons29.182490825653125.7259857654572
232333PALPallidum44.898345947265653.0891399383545
232333RHPRetrohippocampal region46.708038330078153.9592933654785
232333sAMYStriatum-like amygdalar nuclei42.124477386474636.908260345459
232333STRStriatum25.023653030395522.009617805481
232333STRdStriatum dorsal region15.867937088012714.7375292778015
232333STRvStriatum ventral region46.135356903076235.860912322998
232333THThalamus7.25549888610845.21932876110077
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6529GO:0005328IEAFunctionneurotransmitter:sodium symporter activity
6529GO:0005332IEAFunctiongamma-aminobutyric acid:sodium symporter activity
6529GO:0005624TASComponentmembrane fraction
6529GO:0005887IEAComponentintegral to plasma membrane
6529GO:0006836IEAProcessneurotransmitter transport
6529GO:0007268TASProcesssynaptic transmission
6529GO:0015293IEAFunctionsymporter activity
6529GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6804NP_004594.1syntaxin 1A (brain)HPRD01721
NP_003033.16804-Syntaxin 1AHPRD00664
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6529SC6A1_HUMANP30531IPR002980GAT1_transporterGABA neurotransmitter transporter GAT-1
6529SC6A1_HUMANP30531IPR000175Na/ntran_symportSodium:neurotransmitter symporter

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