Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6530
Official Symbol:SLC6A2
Other Aliases:NAT1|NET|NET1|SLC6A5
See related:HGNC:11048|MIM:163970|HPRD:01232
Chromosome:16
Location:16q12.2
Gene Description:solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0229
ORGANISM:human
Entrez Gene ID:6530
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
KARG Evidence 2
KARG ID:QTL0128
ORGANISM:human
Entrez Gene ID:6530
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20538CBCerebellum2.6855214536193.27040532231331
20538CTXCerebral cortex0.542373001575470.869958639144897
20538HIPHippocampal region0.519811838865280.606489539146423
20538HPFHippocampal formation0.559013634920120.571971714496613
20538HYHypothalamus0.1638281755149360.310750365257263
20538LSXLateral septal complex0.1941039338707920.367139741778374
20538MBMidbrain0.4900894016027450.885122656822205
20538MYMedulla1.834422886371612.43225622177124
20538OLFOlfactory bulb0.8756689429283141.58379858732224
20538PPons2.636544942855837.31343173980713
20538PALPallidum0.1121697202324870.112821836024523
20538RHPRetrohippocampal region0.5298359021544460.454173915088177
20538sAMYStriatum-like amygdalar nuclei0.08781041949987410.13913930952549
20538STRStriatum0.1948972716927530.219072423875332
20538STRdStriatum dorsal region0.1835297569632530.224974527955055
20538STRvStriatum ventral region0.2654926367104050.179917730391026
20538THThalamus0.3774036616086960.50091877579689
KARG Evidence 3
KARG ID:QTL0128
Trait:METH responses for body temperature
Peak:45
Peak Marker:D8Ncvs43
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:8987796
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6530GO:0005328IEAFunctionneurotransmitter:sodium symporter activity
6530GO:0005334TASFunctionnorephinephrine:sodium symporter activity
6530GO:0005515IPIFunctionprotein binding
6530GO:0005624TASComponentmembrane fraction
6530GO:0005887IEAComponentintegral to plasma membrane
6530GO:0005887TASComponentintegral to plasma membrane
6530GO:0006836IEAProcessneurotransmitter transport
6530GO:0007268TASProcesssynaptic transmission
6530GO:0008504IDAFunctionmonoamine transporter activity
6530GO:0015293IEAFunctionsymporter activity
6530GO:0015844IDAProcessmonoamine transport
6530GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6530SC6A2_HUMANP23975IPR000175Na/ntran_symportSodium:neurotransmitter symporter
6530SC6A2_HUMANP23975IPR002435Nor_transporterNoradrenaline neurotransmitter transporter

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