Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6531
Official Symbol:SLC6A3
Other Aliases:DAT|DAT1
See related:HGNC:11049|MIM:126455|HPRD:00543
Chromosome:5
Location:5p15.3
Gene Description:solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0034
ORGANISM:human
Entrez Gene ID:6531
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:9925040
Addiction Drug:NICOTINE
Addiction Drug Detail:NICOTINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIL0107
ORGANISM:human
Entrez Gene ID:6531
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:14732864
Addiction Drug:NICOTINE
Addiction Drug Detail:NICOTINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIL0130
ORGANISM:human
Entrez Gene ID:6531
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15381926
Addiction Drug:NICOTINE
Addiction Drug Detail:NICOTINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13162CBCerebellum0.7290850430727011.37438499927521
13162CTXCerebral cortex0.6549137979745860.707634687423706
13162HIPHippocampal region0.6433576680719850.568460930138826
13162HPFHippocampal formation0.7703480795025830.717013537883759
13162HYHypothalamus1.531311213970182.18081748485565
13162LSXLateral septal complex0.1225683428347110.172053046524525
13162MBMidbrain5.717991352081316.8128900527954
13162MYMedulla0.3889856189489360.544968530535698
13162OLFOlfactory bulb1.417454749345781.34388655424118
13162PPons0.9123451113700871.70475089550018
13162PALPallidum0.3023039326071740.412785388529301
13162RHPRetrohippocampal region1.00144141912460.926953941583633
13162sAMYStriatum-like amygdalar nuclei0.2730441465973850.228618294000626
13162STRStriatum0.2868982329964640.324361115694046
13162STRdStriatum dorsal region0.2866980805993080.276514485478401
13162STRvStriatum ventral region0.3863423913717270.610262714326382
13162THThalamus0.5818156301975250.480234667658806
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6531GO:0005330IEAFunctiondopamine:sodium symporter activity
6531GO:0005515IPIFunctionprotein binding
6531GO:0005737TASComponentcytoplasm
6531GO:0005886IDAComponentplasma membrane
6531GO:0005887IEAComponentintegral to plasma membrane
6531GO:0008504IDAFunctionmonoamine transporter activity
6531GO:0015293IEAFunctionsymporter activity
6531GO:0015844IDAProcessmonoamine transport
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_001035.1--PICK1HPRD00543
NP_001035.16622--BIND181924
NP_001035.16622NP_000336.1alpha-synuclein isoform NACP140HPRD01227
NP_001035.16622NP_000336.1alpha-synuclein isoform NACP140HPRD00543
NP_001035.16531NP_001035.1solute carrier family 6 (neurotransmitter transporter, dopamine), member 3BIND196818
NP_001035.16804NP_004594.1syntaxin 1A (brain)BIND196816
NP_001035.110399NP_006089.1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1BIND196813
NP_001035.19463NP_036539.1protein interacting with C kinase 1HPRD16176
NP_001035.17041NP_057011.2androgen receptor coactivator ARA55HPRD00543
NP_001035.17041NP_057011.2androgen receptor coactivator ARA55HPRD03831
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6531SC6A3_HUMANQ01959IPR002436Dop_transporterDopamine neurotransmitter transporter
6531SC6A3_HUMANQ01959IPR000175Na/ntran_symportSodium:neurotransmitter symporter

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