Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6532
Official Symbol:SLC6A4
Other Aliases:5-HTT|5HTT|HTT|OCD1|SERT|hSERT
See related:HGNC:11050|MIM:182138|HPRD:01640
Chromosome:17
Location:17q11.1-q12
Gene Description:solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0073
ORGANISM:human
Entrez Gene ID:6532
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:12173460
Addiction Drug:OPIOIDS
Addiction Drug Detail:OPIATE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIL0143
ORGANISM:human
Entrez Gene ID:6532
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15581469
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIL0157
ORGANISM:human
Entrez Gene ID:6532
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15806583
Addiction Drug:NICOTINE
Addiction Drug Detail:NICOTINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 4
KARG ID:EVIL0194
ORGANISM:human
Entrez Gene ID:6532
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:16109588
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
15567CBCerebellum1.015803605318071.20080131292343
15567CTXCerebral cortex0.3957595601677890.281486257910728
15567HIPHippocampal region0.5195316970348360.543971784412861
15567HPFHippocampal formation0.4347969703376290.411085046827793
15567HYHypothalamus0.3474885374307630.293204039335251
15567LSXLateral septal complex0.5619248151779170.795169115066528
15567MBMidbrain1.795305371284483.21735596656799
15567MYMedulla3.043460130691533.9730441570282
15567OLFOlfactory bulb7.323469936847693.27408581972122
15567PPons2.338987231254584.1085798740387
15567PALPallidum0.4232512339949610.261636566370726
15567RHPRetrohippocampal region0.2999011874198910.243425957858562
15567sAMYStriatum-like amygdalar nuclei2.129690766334531.75797583162785
15567STRStriatum0.6980766654014590.569367475807667
15567STRdStriatum dorsal region0.7111291885375980.505441322922707
15567STRvStriatum ventral region0.196072131395340.308780945837498
15567THThalamus0.590345382690430.509397581219673
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6532GO:0001504TASProcessneurotransmitter uptake
6532GO:0005335IEAFunctionserotonin:sodium symporter activity
6532GO:0005515IPIFunctionprotein binding
6532GO:0005887TASComponentintegral to plasma membrane
6532GO:0006837TASProcessserotonin transport
6532GO:0008504IDAFunctionmonoamine transporter activity
6532GO:0015222TASFunctionserotonin transporter activity
6532GO:0015293IEAFunctionsymporter activity
6532GO:0015844IDAProcessmonoamine transport
6532GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6804NP_004594.1syntaxin 1A (brain)HPRD01721
NP_001036.16804-Syntaxin 1AHPRD01640
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6532SC6A4_HUMANP31645IPR0130865HT_transport_NSerotonin (5-HT) neurotransmitter transporter, N-terminal
6532SC6A4_HUMANP31645IPR000175Na/ntran_symportSodium:neurotransmitter symporter

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