Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:655
Official Symbol:BMP7
Other Aliases:OP-1
See related:HGNC:1074|MIM:112267|HPRD:00212
Chromosome:20
Location:20q13
Gene Description:bone morphogenetic protein 7 (osteogenic protein 1)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0882
ORGANISM:human
Entrez Gene ID:655
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.6 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12162CBCerebellum8.044482946395877.9749219417572
12162CTXCerebral cortex2.274132072925571.90129917860031
12162HIPHippocampal region1.503650814294821.05170623958111
12162HPFHippocampal formation2.993473529815672.58087944984436
12162HYHypothalamus1.205589979887010.736159831285477
12162LSXLateral septal complex0.7109091877937320.521885097026825
12162MBMidbrain1.62665534019472.2568706870079
12162MYMedulla4.838773727416993.07697153091431
12162OLFOlfactory bulb6.548816442489624.94156289100647
12162PPons2.980934381484993.43358755111694
12162PALPallidum0.3936930745840070.268002428114414
12162RHPRetrohippocampal region4.96893143653874.16398203372955
12162sAMYStriatum-like amygdalar nuclei0.5644274801015850.464102566242218
12162STRStriatum0.3374673128128050.235690727829933
12162STRdStriatum dorsal region0.163529530167580.110433779656887
12162STRvStriatum ventral region0.5909401774406430.330563686788082
12162THThalamus2.025733888149261.19083005189896
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
655GO:0001503IEAProcessossification
655GO:0005125IEAFunctioncytokine activity
655GO:0005615IEAComponentextracellular space
655GO:0008083IEAFunctiongrowth factor activity
655GO:0030154IEAProcesscell differentiation
655GO:0040007IEAProcessgrowth
655GO:0051216IEAProcesscartilage development
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-658NP_001194.1bone morphogenetic protein receptor, type IBHPRD04457
-659NP_001195.2bone morphogenetic protein receptor type II precursorHPRD02880
NP_001710.1659-BMP receptor, type 2HPRD00212
NP_001710.1658-Bone morphogenetic protein receptor, type IBHPRD00212
NP_001710.12022NP_000109.1endoglin precursorHPRD00212
NP_001710.12022NP_000109.1endoglin precursorHPRD00565
NP_001710.1657NP_004320.1bone morphogenetic protein receptor, type IA precursorHPRD00212
NP_001710.1657NP_004320.1bone morphogenetic protein receptor, type IA precursorHPRD03192
NP_001710.19241NP_005441.1noggin precursorHPRD04291
NP_001710.19241NP_005441.1noggin precursorHPRD00212
NP_001710.18202NP_006525.1nuclear receptor coactivator 3HPRD00212
NP_001710.18202NP_006525.1nuclear receptor coactivator 3HPRD03570
NP_001710.125928NP_056279.1cystine knot-containing secreted proteinHPRD15417
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
655BMP7_HUMANP18075IPR001839TGFbTransforming growth factor beta
655BMP7_HUMANP18075IPR001111TGFb_NTransforming growth factor beta (TGFb), N-terminal
655BMP7_HUMANP18075IPR003911TGF_TGFbTransforming growth factor beta TGFb

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