Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6554
Official Symbol:SLC10A1
Other Aliases:NTCP|NTCP1
See related:HGNC:10905|MIM:182396|HPRD:01672
Chromosome:14
Location:14q24.1
Gene Description:solute carrier family 10 (sodium/bile acid cotransporter family), member 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0134
ORGANISM:human
Entrez Gene ID:6554
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:-2.60 :: -1.79 :: -2.10 :: -1.75 :: 1.00 :: 1.20 :: 1.35
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20493CBCerebellum0.9326431155204771.4563285112381
20493CTXCerebral cortex2.245773077011112.70197606086731
20493HIPHippocampal region0.6614171862602230.834594666957855
20493HPFHippocampal formation0.7870117425918580.932989418506622
20493HYHypothalamus0.3635697066783910.376212418079376
20493LSXLateral septal complex0.2317108064889910.388899624347687
20493MBMidbrain0.5460256338119510.981130599975586
20493MYMedulla0.4500495791435240.586468756198883
20493OLFOlfactory bulb0.6297766566276550.567934215068817
20493PPons0.3908901810646060.54902046918869
20493PALPallidum0.565526425838471.10745656490326
20493RHPRetrohippocampal region0.8753060698509220.994875907897949
20493sAMYStriatum-like amygdalar nuclei0.3718097209930420.30879619717598
20493STRStriatum0.529530286788940.608602404594421
20493STRdStriatum dorsal region0.6201581358909610.75826221704483
20493STRvStriatum ventral region0.3718513548374180.300157368183136
20493THThalamus0.470768153667450.627051293849945
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6554GO:0005887TASComponentintegral to plasma membrane
6554GO:0006811IEAProcession transport
6554GO:0006814IEAProcesssodium ion transport
6554GO:0008508TASFunctionbile acid:sodium symporter activity
6554GO:0015293IEAFunctionsymporter activity
6554GO:0015711IEAProcessorganic anion transport
6554GO:0016020IEAComponentmembrane
6554GO:0031402IEAFunctionsodium ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6554NTCP_HUMANQ14973IPR002657BilAc/Na_symportBile acid:sodium symporter

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