Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6607
Official Symbol:SMN2
Other Aliases:BCD541|C-BCD541|SMNC
See related:HGNC:11118|MIM:601627|HPRD:09036
Chromosome:5
Location:5q13
Gene Description:survival of motor neuron 2, centromeric
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0410
ORGANISM:human
Entrez Gene ID:6607
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:64301
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20595CBCerebellum100.0100.0
20595CTXCerebral cortex100.0100.0
20595HIPHippocampal region100.0100.0
20595HPFHippocampal formation100.0100.0
20595HYHypothalamus100.0100.0
20595LSXLateral septal complex100.0100.0
20595MBMidbrain100.0100.0
20595MYMedulla100.0100.0
20595OLFOlfactory bulb100.0100.0
20595PPons100.0100.0
20595PALPallidum100.0100.0
20595RHPRetrohippocampal region100.0100.0
20595sAMYStriatum-like amygdalar nuclei100.0100.0
20595STRStriatum100.0100.0
20595STRdStriatum dorsal region100.0100.0
20595STRvStriatum ventral region100.0100.0
20595THThalamus100.0100.0
KARG Evidence 2
KARG ID:HOT0057
Entrez Gene ID:6607
RefSeq ID:NM_022877
Position Information:+, Enhancer, 42814bp
Linkage Marker:rs3379
Evidence Type:ASSOCIATION GENOME SCANNING
Evidence Name:PUBMED
Evidence ID:11704927
Addiction Drug:POLYSUBSTANCE
Addiction Drug Detail:POLYSUBSTANCE ABUSE
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_059107.1--GEMIN4HPRD09036
NP_059107.16628NP_003082.1small nuclear ribonucleoprotein polypeptide B/B' isoform BHPRD09036
NP_059107.16629NP_003083.1small nuclear ribonucleoprotein polypeptide B''HPRD09036
NP_059107.16629NP_003083.1small nuclear ribonucleoprotein polypeptide B''HPRD04628
NP_059107.16635NP_003085.1small nuclear ribonucleoprotein polypeptide EHPRD09036
NP_059107.16635NP_003085.1small nuclear ribonucleoprotein polypeptide EHPRD00548
NP_059107.16636NP_003086.1small nuclear ribonucleoprotein polypeptide FHPRD09036
NP_059107.16636NP_003086.1small nuclear ribonucleoprotein polypeptide FHPRD04645
NP_059107.16637NP_003087.1small nuclear ribonucleoprotein polypeptide GHPRD09036
NP_059107.18487NP_003607.1SMN-interacting protein 1 isoform alphaHPRD09036
NP_059107.16634NP_004166.1small nuclear ribonucleoprotein polypeptide D3HPRD03039
NP_059107.16634NP_004166.1small nuclear ribonucleoprotein polypeptide D3HPRD09036
NP_059107.16633NP_004588.1small nuclear ribonucleoprotein polypeptide D2HPRD09036
NP_059107.16632NP_008869.1small nuclear ribonucleoprotein D1 polypeptide 16kDaHPRD09036
NP_059107.111218NP_009135.3DEAD (Asp-Glu-Ala-Asp) box polypeptide 20HPRD09036
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6607IPR000694PRO_richProline-rich region
6607IPR010304SMNSurvival motor neuron
6607IPR002999TudorTudor
6607SMN_HUMANQ16637IPR000694PRO_richProline-rich region
6607SMN_HUMANQ16637IPR010304SMNSurvival motor neuron
6607SMN_HUMANQ16637IPR002999TudorTudor

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