Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6610
Official Symbol:SMPD2
Other Aliases:NSMASE
See related:HGNC:11121|MIM:603498|HPRD:04608
Chromosome:6
Location:6q21
Gene Description:sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0180
ORGANISM:human
Entrez Gene ID:6610
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15312160
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:-
KARG Evidence 2
KARG ID:EVIM0186
ORGANISM:human
Entrez Gene ID:6610
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15312160
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20598CBCerebellum1.278727412223822.1408360004425
20598CTXCerebral cortex0.439750432968140.892356753349304
20598HIPHippocampal region1.950631380081182.41834592819214
20598HPFHippocampal formation1.722856283187872.1750853061676
20598HYHypothalamus7.747486114501957.56763219833374
20598LSXLateral septal complex0.4198530316352840.405977040529251
20598MBMidbrain2.177279710769653.86528158187866
20598MYMedulla1.920182824134833.58656525611877
20598OLFOlfactory bulb4.145251750946045.69212675094604
20598PPons5.6829648017883310.070104598999
20598PALPallidum1.84388005733491.85651898384094
20598RHPRetrohippocampal region1.295243382453921.92458653450012
20598sAMYStriatum-like amygdalar nuclei7.3935518264770510.0270624160767
20598STRStriatum1.636015772819522.03315758705139
20598STRdStriatum dorsal region0.07467684149742130.167239397764206
20598STRvStriatum ventral region3.64114975929263.56940031051636
20598THThalamus0.9667045474052431.18256771564484
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6610GO:0000287IEAFunctionmagnesium ion binding
6610GO:0004767TASFunctionsphingomyelin phosphodiesterase activity
6610GO:0005887TASComponentintegral to plasma membrane
6610GO:0006684TASProcesssphingomyelin metabolism
6610GO:0016020IEAComponentmembrane
6610GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6610NSMA_HUMANO60906IPR005135Exo_endo_phosEndonuclease/exonuclease/phosphatase

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.