Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6622
Official Symbol:SNCA
Other Aliases:MGC110988|NACP|PARK1|PARK4|PD1
See related:HGNC:11138|MIM:163890|HPRD:01227
Chromosome:4
Location:4q21
Gene Description:synuclein, alpha (non A4 component of amyloid precursor)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0152
ORGANISM:human
Entrez Gene ID:6622
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15731118
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE, WITHDRAW
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0371
ORGANISM:human
Entrez Gene ID:6622
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:1.2 :: 1.5 :: 1.5 :: -1.2 :: 1.1 :: -1.5 :: -1.5
KARG Evidence 3
KARG ID:EVIM0439
ORGANISM:human
Entrez Gene ID:6622
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.5 :: -1.6 :: -1.7 :: 1.3 :: -1.2
KARG Evidence 4
KARG ID:EVIM0870
ORGANISM:human
Entrez Gene ID:6622
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.6 :: 1.4 :: -1.1 :: 1.4
KARG Evidence 5
KARG ID:EVIP0203
ORGANISM:human
Entrez Gene ID:6622
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:15542695
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Whole Brain
Drug Effects:Downregulated
Fold Change:0.17
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20617CBCerebellum8.351166486740116.94073351224263
20617CTXCerebral cortex85.226927439371785.2985038757324
20617HIPHippocampal region97.5315424601237100.0
20617HPFHippocampal formation91.3941472371419100.0
20617HYHypothalamus15.492876728375813.72984735171
20617LSXLateral septal complex35.923199733098431.3725252946218
20617MBMidbrain18.538993517557822.4079847335815
20617MYMedulla16.724916458129917.1770013173421
20617OLFOlfactory bulb89.133631388346491.1513214111328
20617PPons16.789230505625419.7989474932353
20617PALPallidum21.51508347193420.7619361480077
20617RHPRetrohippocampal region83.574475606282585.0894889831543
20617sAMYStriatum-like amygdalar nuclei40.043066660563138.1963129043579
20617STRStriatum56.628288586934448.4007431666056
20617STRdStriatum dorsal region55.117579142252647.5256231625875
20617STRvStriatum ventral region70.116297403971458.0702196756999
20617THThalamus17.924576282501217.7613689104716
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6622GO:0005515IPIFunctionprotein binding
6622GO:0005737TASComponentcytoplasm
6622GO:0006916TASProcessanti-apoptosis
6622GO:0007417TASProcesscentral nervous system development
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7529NP_003395.1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideHPRD03184
-8878NP_003891.1sequestosome 1HPRD03319
-7345NP_004172.2ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)HPRD01877
-9479NP_005447.1mitogen-activated protein kinase 8 interacting protein 1HPRD05223
-9627NP_005451.1synuclein alpha interacting proteinHPRD04804
-7846NP_006000.2tubulin, alpha 3HPRD03959
-54205NP_061820.1cytochrome cHPRD00479
-84570NP_942014.1collagen, type XXV, alpha 1 isoform 1HPRD09886
-7054NP_954986.1tyrosine hydroxylase isoform aHPRD01865
NP_000336.1--AbetaHPRD01227
NP_000336.1--DATHPRD01227
NP_000336.1---BIND185527
NP_000336.19627-Synphilin 1HPRD01227
NP_000336.17529-14-3-3 BetaHPRD01227
NP_000336.154205-Cytochrome CHPRD01227
NP_000336.18878-Sequestome 1HPRD01227
NP_000336.17345-Ubiquitin carboxyl terminal esterase L1HPRD01227
NP_000336.17846-Tubulin, alpha, brain specificHPRD01227
NP_000336.19479-MAPK8 interacting protein 1HPRD01227
NP_000336.17054-Tyrosine hydroxylaseHPRD01227
NP_000336.19627NP_005451.1synuclein alpha interacting proteinBIND181898
NP_000336.17531NP_006752.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptideHPRD05457
NP_000336.17531NP_006752.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptideHPRD01227
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6622SYUA_HUMANP37840IPR001058SynucleinSynuclein
6622SYUA_HUMANP37840IPR002460Synuclein_alphaAlpha-synuclein
6622SYUA_HUMANP37840IPR002462Synuclein_gammaGamma-synuclein

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