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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry

For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information Gene ID: 6622 Official Symbol: SNCA Other Aliases: MGC110988|NACP|PARK1|PARK4|PD1 See related: HGNC:11138|MIM:163890|HPRD:01227 Chromosome: 4 Location: 4q21 Gene Description: synuclein, alpha (non A4 component of amyloid precursor) Gene type: protein-coding Gene Structure: Genomic Context: KARG Evidence 1 KARG ID: EVIL0152 ORGANISM: human Entrez Gene ID: 6622 Evidence Type: LT Reports Evidence ID Type: PUBMED Evidence ID: 15731118 Addiction Drug: ALCOHOL Addiction Drug Detail: ALCOHOL ABUSE, WITHDRAW Addiction Brain Area: Drug Effects: Fold Change: KARG Evidence 2 KARG ID: EVIM0371 ORGANISM: human Entrez Gene ID: 6622 Evidence Type: Microarray Evidence ID Type: PUBMED Evidence ID: 12065639 Addiction Drug: ALCOHOL Addiction Drug Detail: ALCOHOL ABUSE Addiction Brain Area: Frontal Cortex Drug Effects: Downregulated Fold Change: 1.2 :: 1.5 :: 1.5 :: -1.2 :: 1.1 :: -1.5 :: -1.5 KARG Evidence 3 KARG ID: EVIM0439 ORGANISM: human Entrez Gene ID: 6622 Evidence Type: Microarray Evidence ID Type: PUBMED Evidence ID: 12065639 Addiction Drug: ALCOHOL Addiction Drug Detail: ALCOHOL ABUSE Addiction Brain Area: Motor Cortex Drug Effects: Downregulated Fold Change: -1.5 :: -1.6 :: -1.7 :: 1.3 :: -1.2 KARG Evidence 4 KARG ID: EVIM0870 ORGANISM: human Entrez Gene ID: 6622 Evidence Type: Microarray Evidence ID Type: PUBMED Evidence ID: 11141048 Addiction Drug: ALCOHOL Addiction Drug Detail: ALCOHOL ABUSE Addiction Brain Area: Frontal Cortex Drug Effects: Upregulated Fold Change: 1.6 :: 1.4 :: -1.1 :: 1.4 KARG Evidence 5 KARG ID: EVIP0203 ORGANISM: human Entrez Gene ID: 6622 Evidence Type: Proteomics Evidence ID Type: PUBMED Evidence ID: 15542695 Addiction Drug: ALCOHOL Addiction Drug Detail: ALCOHOL ABUSE Addiction Brain Area: Whole Brain Drug Effects: Downregulated Fold Change: 0.17 Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas) Mouse Entrez Gene ID Brain Region Brain Region Detail Expression Level Expression Density 20617 CB Cerebellum 8.35116648674011 6.94073351224263 20617 CTX Cerebral cortex 85.2269274393717 85.2985038757324 20617 HIP Hippocampal region 97.5315424601237 100.0 20617 HPF Hippocampal formation 91.3941472371419 100.0 20617 HY Hypothalamus 15.4928767283758 13.72984735171 20617 LSX Lateral septal complex 35.9231997330984 31.3725252946218 20617 MB Midbrain 18.5389935175578 22.4079847335815 20617 MY Medulla 16.7249164581299 17.1770013173421 20617 OLF Olfactory bulb 89.1336313883464 91.1513214111328 20617 P Pons 16.7892305056254 19.7989474932353 20617 PAL Pallidum 21.515083471934 20.7619361480077 20617 RHP Retrohippocampal region 83.5744756062825 85.0894889831543 20617 sAMY Striatum-like amygdalar nuclei 40.0430666605631 38.1963129043579 20617 STR Striatum 56.6282885869344 48.4007431666056 20617 STRd Striatum dorsal region 55.1175791422526 47.5256231625875 20617 STRv Striatum ventral region 70.1162974039714 58.0702196756999 20617 TH Thalamus 17.9245762825012 17.7613689104716 Gene Ontology Gene ID GO ID Evidence GO Type GO Description 6622 GO:0005515 IPI Function protein binding 6622 GO:0005737 TAS Component cytoplasm 6622 GO:0006916 TAS Process anti-apoptosis 6622 GO:0007417 TAS Process central nervous system development Interaction Information Gene Product ID Interactant Gene ID Interactant Gene Product ID Interactant Gene Product Name Source Source ID - 7529 NP_003395.1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HPRD 03184 - 8878 NP_003891.1 sequestosome 1 HPRD 03319 - 7345 NP_004172.2 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) HPRD 01877 - 9479 NP_005447.1 mitogen-activated protein kinase 8 interacting protein 1 HPRD 05223 - 9627 NP_005451.1 synuclein alpha interacting protein HPRD 04804 - 7846 NP_006000.2 tubulin, alpha 3 HPRD 03959 - 54205 NP_061820.1 cytochrome c HPRD 00479 - 84570 NP_942014.1 collagen, type XXV, alpha 1 isoform 1 HPRD 09886 - 7054 NP_954986.1 tyrosine hydroxylase isoform a HPRD 01865 NP_000336.1 - - Abeta HPRD 01227 NP_000336.1 - - DAT HPRD 01227 NP_000336.1 - - - BIND 185527 NP_000336.1 9627 - Synphilin 1 HPRD 01227 NP_000336.1 7529 - 14-3-3 Beta HPRD 01227 NP_000336.1 54205 - Cytochrome C HPRD 01227 NP_000336.1 8878 - Sequestome 1 HPRD 01227 NP_000336.1 7345 - Ubiquitin carboxyl terminal esterase L1 HPRD 01227 NP_000336.1 7846 - Tubulin, alpha, brain specific HPRD 01227 NP_000336.1 9479 - MAPK8 interacting protein 1 HPRD 01227 NP_000336.1 7054 - Tyrosine hydroxylase HPRD 01227 NP_000336.1 9627 NP_005451.1 synuclein alpha interacting protein BIND 181898 NP_000336.1 7531 NP_006752.1 tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide HPRD 05457 NP_000336.1 7531 NP_006752.1 tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide HPRD 01227 Domain Information Gene ID Uniprot/Swissprot ID Uniprot/Swissprot ACC Interpro ID Interpro Short Description Interpro Long Description 6622 SYUA_HUMAN P37840 IPR001058 Synuclein Synuclein 6622 SYUA_HUMAN P37840 IPR002460 Synuclein_alpha Alpha-synuclein 6622 SYUA_HUMAN P37840 IPR002462 Synuclein_gamma Gamma-synuclein © Center for Bioinformatics(CBI), Peking University Any Comments and suggestions to : KARG GROUP.