Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6647
Official Symbol:SOD1
Other Aliases:ALS|ALS1|IPOA|SOD|homodimer
See related:HGNC:11179|MIM:147450
Chromosome:21
Location:21q22.1|21q22.11
Gene Description:superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0098
ORGANISM:human
Entrez Gene ID:6647
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.23 :: 2.73 :: 3.50 :: 1.24 :: -1.21 :: -2.35 :: -0.45
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20655CBCerebellum26.001789093017639.1075744628906
20655CTXCerebral cortex46.515709877014247.0069522857666
20655HIPHippocampal region59.249721527099666.6625232696533
20655HPFHippocampal formation57.294384002685566.2586116790771
20655HYHypothalamus78.589059829711974.4295063018799
20655LSXLateral septal complex50.986296653747647.7504858970642
20655MBMidbrain38.867258071899450.2660646438599
20655MYMedulla38.372264862060561.5681476593018
20655OLFOlfactory bulb77.786727905273475.6892547607422
20655PPons43.076030731201265.5245323181152
20655PALPallidum69.012857437133876.0452823638916
20655RHPRetrohippocampal region56.408185958862358.3685283660889
20655sAMYStriatum-like amygdalar nuclei52.412963867187547.5555858612061
20655STRStriatum42.76865100860639.9363031387329
20655STRdStriatum dorsal region28.304524898529126.5484364032745
20655STRvStriatum ventral region81.851730346679773.0518569946289
20655THThalamus38.158500671386743.7106113433838
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6647GO:0004785TASFunctioncopper, zinc superoxide dismutase activity
6647GO:0005507IEAFunctioncopper ion binding
6647GO:0005737NRComponentcytoplasm
6647GO:0006801IEAProcesssuperoxide metabolism
6647GO:0006979NRProcessresponse to oxidative stress
6647GO:0007399TASProcessnervous system development
6647GO:0008270IEAFunctionzinc ion binding
6647GO:0016209IEAFunctionantioxidant activity
6647GO:0016491IEAFunctionoxidoreductase activity
6647GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
CAA26182.19973NP_005116.1copper chaperone for superoxide dismutaseHPRD00937
CAA26182.19973NP_005116.1copper chaperone for superoxide dismutaseHPRD04841
NC_000021.763897NP_071353.3hypothetical protein LOC63897BIND315570
NP_000445.19973NP_005116.1copper chaperone for superoxide dismutaseBIND185691
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6647SODC_HUMANP00441IPR001424SOD_Cu_ZnSuperoxide dismutase, copper/zinc binding

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