Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6648
Official Symbol:SOD2
Other Aliases:IPO-B|MNSOD|Mn-SOD
See related:HGNC:11180|MIM:147460|HPRD:00938
Chromosome:6
Location:6q25.3
Gene Description:superoxide dismutase 2, mitochondrial
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0317
ORGANISM:human
Entrez Gene ID:6648
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:20656
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20656CBCerebellum0.00.0
20656CTXCerebral cortex0.00.0
20656HIPHippocampal region0.00.0
20656HPFHippocampal formation0.00.0
20656HYHypothalamus0.00.0
20656LSXLateral septal complex0.00.0
20656MBMidbrain0.00.0
20656MYMedulla0.00.0
20656OLFOlfactory bulb0.00.0
20656PPons0.00.0
20656PALPallidum0.00.0
20656RHPRetrohippocampal region0.00.0
20656sAMYStriatum-like amygdalar nuclei0.00.0
20656STRStriatum0.00.0
20656STRdStriatum dorsal region0.00.0
20656STRvStriatum ventral region0.00.0
20656THThalamus0.00.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6648GO:0000303ISSProcessresponse to superoxide
6648GO:0000303TASProcessresponse to superoxide
6648GO:0001315IMPProcessage-dependent response to reactive oxygen species
6648GO:0001315ISSProcessage-dependent response to reactive oxygen species
6648GO:0004784IEAFunctionsuperoxide dismutase activity
6648GO:0005739TASComponentmitochondrion
6648GO:0006357IMPProcessregulation of transcription from RNA polymerase II promoter
6648GO:0006357ISSProcessregulation of transcription from RNA polymerase II promoter
6648GO:0006801IDAProcesssuperoxide metabolism
6648GO:0006801IEAProcesssuperoxide metabolism
6648GO:0006979TASProcessresponse to oxidative stress
6648GO:0008383IDAFunctionmanganese superoxide dismutase activity
6648GO:0016066IMPProcesscellular defense response (sensu Vertebrata)
6648GO:0016066ISSProcesscellular defense response (sensu Vertebrata)
6648GO:0016491IEAFunctionoxidoreductase activity
6648GO:0030145IEAFunctionmanganese ion binding
6648GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000627.16648NP_000627.1superoxide dismutase 2, mitochondrialHPRD00938
NP_000627.1155871NP_057853.1Tat--
NP_000627.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6648IPR001189SODismutaseManganese and iron superoxide dismutase
6648SODM_HUMANP04179IPR001189SODismutaseManganese and iron superoxide dismutase

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