Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6662
Official Symbol:SOX9
Other Aliases:CMD1|CMPD1|SRA1
See related:HGNC:11204|MIM:608160|HPRD:06427
Chromosome:17
Location:17q24.3-q25.1
Gene Description:SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0219
ORGANISM:human
Entrez Gene ID:6662
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:20682
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0230
ORGANISM:human
Entrez Gene ID:6662
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Downregulated
Fold Change:At least 2-folds difference
KARG Evidence 3
KARG ID:EVIM0406
ORGANISM:human
Entrez Gene ID:6662
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1 :: -2 :: -1.5 :: -1.5 :: -1.7 :: -1.5
KARG Evidence 4
KARG ID:EVIM0474
ORGANISM:human
Entrez Gene ID:6662
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1 :: -1 :: 1.1 :: -1.9 :: -1.1
KARG Evidence 5
KARG ID:EVIM0874
ORGANISM:human
Entrez Gene ID:6662
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.4 :: -1.9 :: -1.5 :: -1.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20682CBCerebellum2.796868860721593.36448419094086
20682CTXCerebral cortex0.4994839429855350.638276964426041
20682HIPHippocampal region0.5878608077764510.618694081902504
20682HPFHippocampal formation1.157762080430980.998110294342041
20682HYHypothalamus0.7901798486709590.611546814441681
20682LSXLateral septal complex0.3355669975280760.744934193789959
20682MBMidbrain0.8569895923137660.836585849523544
20682MYMedulla4.026766896247862.54906779527664
20682OLFOlfactory bulb2.035129427909852.04471373558044
20682PPons1.901146411895751.3356357216835
20682PALPallidum1.279263377189640.832639634609222
20682RHPRetrohippocampal region2.015427887439731.52656990289688
20682sAMYStriatum-like amygdalar nuclei0.7526277825236320.525222092866898
20682STRStriatum0.5059105604887010.46065990626812
20682STRdStriatum dorsal region0.2435152530670170.351062685251236
20682STRvStriatum ventral region1.353097915649410.64933118224144
20682THThalamus0.2897069826722150.265243254601955
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6662GO:0001501NRProcessskeletal development
6662GO:0001502NRProcesscartilage condensation
6662GO:0003677IEAFunctionDNA binding
6662GO:0003704TASFunctionspecific RNA polymerase II transcription factor activity
6662GO:0005634TASComponentnucleus
6662GO:0006350IEAProcesstranscription
6662GO:0006357TASProcessregulation of transcription from RNA polymerase II promoter
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000337.1--TRAP230HPRD06427
NP_000337.123013NP_055816.2spen homolog, transcriptional regulatorHPRD06427
NP_000337.123013NP_055816.2spen homolog, transcriptional regulatorHPRD10230
NP_000337.17186NP_066961.2TNF receptor-associated factor 2HPRD06427
NP_000337.17186NP_066961.2TNF receptor-associated factor 2HPRD03538
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6662SOX9_HUMANP48436IPR013558CTNNB1_bd_NCTNNB1 binding, N-teminal
6662SOX9_HUMANP48436IPR000135HMG_1/2High mobility group box HMG1 and HMG2
6662SOX9_HUMANP48436IPR000910HMG_1/2_boxHMG1/2 (high mobility group) box
6662SOX9_HUMANP48436IPR000694PRO_richProline-rich region

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