| Basic Information | | Gene ID: | 6662 | | Official Symbol: | SOX9 | | Other Aliases: | CMD1|CMPD1|SRA1 | | See related: | HGNC:11204|MIM:608160|HPRD:06427 | | Chromosome: | 17 | | Location: | 17q24.3-q25.1 | | Gene Description: | SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal) | | Gene type: | protein-coding | | Gene Structure: |  | | Genomic Context: |  |
| KARG Evidence 1 | | KARG ID: | EVIC0219 | | ORGANISM: | human | | Entrez Gene ID: | 6662 | | Evidence Type: | Mapping from mouse | | Evidence ID Type: | Entrez Gene | | Evidence ID: | 20682 | | Addiction Drug: | | | Addiction Drug Detail: | | | Addiction Brain Area: | | | Drug Effects: | | | Fold Change: | |
| KARG Evidence 2 | | KARG ID: | EVIM0230 | | ORGANISM: | human | | Entrez Gene ID: | 6662 | | Evidence Type: | Microarray | | Evidence ID Type: | PUBMED | | Evidence ID: | 11093800 | | Addiction Drug: | ALCOHOL | | Addiction Drug Detail: | ALCOHOL ADMINISTRATION | | Addiction Brain Area: | SH-SY5Y neuroblastoma cells | | Drug Effects: | Downregulated | | Fold Change: | At least 2-folds difference |
| KARG Evidence 3 | | KARG ID: | EVIM0406 | | ORGANISM: | human | | Entrez Gene ID: | 6662 | | Evidence Type: | Microarray | | Evidence ID Type: | PUBMED | | Evidence ID: | 12065639 | | Addiction Drug: | ALCOHOL | | Addiction Drug Detail: | ALCOHOL ABUSE | | Addiction Brain Area: | Frontal Cortex | | Drug Effects: | Downregulated | | Fold Change: | -1 :: -2 :: -1.5 :: -1.5 :: -1.7 :: -1.5 |
| KARG Evidence 4 | | KARG ID: | EVIM0474 | | ORGANISM: | human | | Entrez Gene ID: | 6662 | | Evidence Type: | Microarray | | Evidence ID Type: | PUBMED | | Evidence ID: | 12065639 | | Addiction Drug: | ALCOHOL | | Addiction Drug Detail: | ALCOHOL ABUSE | | Addiction Brain Area: | Motor Cortex | | Drug Effects: | Downregulated | | Fold Change: | -1 :: -1 :: 1.1 :: -1.9 :: -1.1 |
| KARG Evidence 5 | | KARG ID: | EVIM0874 | | ORGANISM: | human | | Entrez Gene ID: | 6662 | | Evidence Type: | Microarray | | Evidence ID Type: | PUBMED | | Evidence ID: | 11141048 | | Addiction Drug: | ALCOHOL | | Addiction Drug Detail: | ALCOHOL ABUSE | | Addiction Brain Area: | Frontal Cortex | | Drug Effects: | Downregulated | | Fold Change: | -1.4 :: -1.9 :: -1.5 :: -1.5 |
| Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas) | | Mouse Entrez Gene ID | Brain Region | Brain Region Detail | Expression Level | Expression Density | 20682 | CB | Cerebellum | 2.79686886072159 | 3.36448419094086 | 20682 | CTX | Cerebral cortex | 0.499483942985535 | 0.638276964426041 | 20682 | HIP | Hippocampal region | 0.587860807776451 | 0.618694081902504 | 20682 | HPF | Hippocampal formation | 1.15776208043098 | 0.998110294342041 | 20682 | HY | Hypothalamus | 0.790179848670959 | 0.611546814441681 | 20682 | LSX | Lateral septal complex | 0.335566997528076 | 0.744934193789959 | 20682 | MB | Midbrain | 0.856989592313766 | 0.836585849523544 | 20682 | MY | Medulla | 4.02676689624786 | 2.54906779527664 | 20682 | OLF | Olfactory bulb | 2.03512942790985 | 2.04471373558044 | 20682 | P | Pons | 1.90114641189575 | 1.3356357216835 | 20682 | PAL | Pallidum | 1.27926337718964 | 0.832639634609222 | 20682 | RHP | Retrohippocampal region | 2.01542788743973 | 1.52656990289688 | 20682 | sAMY | Striatum-like amygdalar nuclei | 0.752627782523632 | 0.525222092866898 | 20682 | STR | Striatum | 0.505910560488701 | 0.46065990626812 | 20682 | STRd | Striatum dorsal region | 0.243515253067017 | 0.351062685251236 | 20682 | STRv | Striatum ventral region | 1.35309791564941 | 0.64933118224144 | 20682 | TH | Thalamus | 0.289706982672215 | 0.265243254601955 |
| Gene Ontology | | Gene ID | GO ID | Evidence | GO Type | GO Description | | 6662 | GO:0001501 | NR | Process | skeletal development | | 6662 | GO:0001502 | NR | Process | cartilage condensation | | 6662 | GO:0003677 | IEA | Function | DNA binding | | 6662 | GO:0003704 | TAS | Function | specific RNA polymerase II transcription factor activity | | 6662 | GO:0005634 | TAS | Component | nucleus | | 6662 | GO:0006350 | IEA | Process | transcription | | 6662 | GO:0006357 | TAS | Process | regulation of transcription from RNA polymerase II promoter |
| Interaction Information | | Gene Product ID | Interactant Gene ID | Interactant Gene Product ID | Interactant Gene Product Name | Source | Source ID | | NP_000337.1 | - | - | TRAP230 | HPRD | 06427 | | NP_000337.1 | 23013 | NP_055816.2 | spen homolog, transcriptional regulator | HPRD | 06427 | | NP_000337.1 | 23013 | NP_055816.2 | spen homolog, transcriptional regulator | HPRD | 10230 | | NP_000337.1 | 7186 | NP_066961.2 | TNF receptor-associated factor 2 | HPRD | 06427 | | NP_000337.1 | 7186 | NP_066961.2 | TNF receptor-associated factor 2 | HPRD | 03538 |
| Domain Information | | Gene ID | Uniprot/Swissprot ID | Uniprot/Swissprot ACC | Interpro ID | Interpro Short Description | Interpro Long Description | | 6662 | SOX9_HUMAN | P48436 | IPR013558 | CTNNB1_bd_N | CTNNB1 binding, N-teminal | | 6662 | SOX9_HUMAN | P48436 | IPR000135 | HMG_1/2 | High mobility group box HMG1 and HMG2 | | 6662 | SOX9_HUMAN | P48436 | IPR000910 | HMG_1/2_box | HMG1/2 (high mobility group) box | | 6662 | SOX9_HUMAN | P48436 | IPR000694 | PRO_rich | Proline-rich region |
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