Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6663
Official Symbol:SOX10
Other Aliases:DOM|MGC15649|WS4
See related:HGNC:11190|MIM:602229|HPRD:03752
Chromosome:22
Location:22q13.1
Gene Description:SRY (sex determining region Y)-box 10
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0241
ORGANISM:human
Entrez Gene ID:6663
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:20665
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20665CBCerebellum64.435073852539168.648962020874
20665CTXCerebral cortex81.592884063720764.3400993347168
20665HIPHippocampal region78.969600677490267.2475414276123
20665HPFHippocampal formation80.773244857788166.515796661377
20665HYHypothalamus91.220802307128968.1568202972412
20665LSXLateral septal complex100.078.2797718048096
20665MBMidbrain93.755531311035268.8835582733154
20665MYMedulla98.491355895996172.4028854370117
20665OLFOlfactory bulb96.801849365234476.6173057556152
20665PPons100.073.5387802124023
20665PALPallidum97.185028076171972.7271633148193
20665RHPRetrohippocampal region83.572120666503965.2426271438599
20665sAMYStriatum-like amygdalar nuclei88.154674530029365.9691286087036
20665STRStriatum89.555088043212968.2785224914551
20665STRdStriatum dorsal region88.029800415039168.2518005371094
20665STRvStriatum ventral region86.77702713012766.2994556427002
20665THThalamus92.483634948730568.726245880127
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6663GO:0003677IEAFunctionDNA binding
6663GO:0003702TASFunctionRNA polymerase II transcription factor activity
6663GO:0003713TASFunctiontranscription coactivator activity
6663GO:0005634IEAComponentnucleus
6663GO:0006350IEAProcesstranscription
6663GO:0006357TASProcessregulation of transcription from RNA polymerase II promoter
6663GO:0007605IEAProcesssensory perception of sound
6663GO:0009653TASProcessmorphogenesis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_008872.1--Pax3HPRD03752
NP_008872.16663NP_008872.1SRY (sex determining region Y)-box 10BIND185308
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6663SOX10_HUMANP56693IPR013558CTNNB1_bd_NCTNNB1 binding, N-teminal
6663SOX10_HUMANP56693IPR000135HMG_1/2High mobility group box HMG1 and HMG2
6663SOX10_HUMANP56693IPR000910HMG_1/2_boxHMG1/2 (high mobility group) box

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