Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6678
Official Symbol:SPARC
Other Aliases:ON
See related:HGNC:11219|MIM:182120|HPRD:01631
Chromosome:5
Location:5q31.3-q32
Gene Description:secreted protein, acidic, cysteine-rich (osteonectin)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0171
ORGANISM:human
Entrez Gene ID:6678
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:20692
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0231
ORGANISM:human
Entrez Gene ID:6678
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Downregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20692CBCerebellum62.298543294270876.0959752400716
20692CTXCerebral cortex44.085841496785536.8497492472331
20692HIPHippocampal region42.282995859781953.0530846913656
20692HPFHippocampal formation43.169009526570647.9747187296549
20692HYHypothalamus64.742654641469368.2593770027161
20692LSXLateral septal complex42.940524101257350.2061850229899
20692MBMidbrain66.062033971150770.6280377705892
20692MYMedulla73.398204803466876.1122188568115
20692OLFOlfactory bulb59.870970408121757.7969379425049
20692PPons67.671614329020269.9298639297485
20692PALPallidum62.154369990030968.808939297994
20692RHPRetrohippocampal region43.5505161285439.9165754318237
20692sAMYStriatum-like amygdalar nuclei48.194181124369351.4053751627604
20692STRStriatum36.640501340230333.9866530100505
20692STRdStriatum dorsal region31.307574907938628.1158056259155
20692STRvStriatum ventral region44.035252253214534.9556204477946
20692THThalamus58.480538368225165.8963015874227
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6678GO:0001503TASProcessossification
6678GO:0005507IEAFunctioncopper ion binding
6678GO:0005509IEAFunctioncalcium ion binding
6678GO:0005509TASFunctioncalcium ion binding
6678GO:0005518TASFunctioncollagen binding
6678GO:0005604IEAComponentbasement membrane
6678GO:0007169NASProcesstransmembrane receptor protein tyrosine kinase signaling pathway
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7422NP_003367.2vascular endothelial growth factorHPRD01889
NP_003109.1--PDGF alphaHPRD01631
NP_003109.1--Collagen IHPRD01631
NP_003109.1--Collagen IIHPRD01631
NP_003109.1--Collagen IIIHPRD01631
NP_003109.1--Collagen IVHPRD01631
NP_003109.1--Collagen VHPRD01631
NP_003109.1--Collagen VIHPRD01631
NP_003109.1--Collagen VIIIHPRD01631
NP_003109.1--FibrinogenHPRD01631
NP_003109.1--FibronectinHPRD01631
NP_003109.1--LamininHPRD01631
NP_003109.1--Procollagen type IHPRD01631
NP_003109.17422-VEGF AHPRD01631
NP_003109.17040NP_000651.1transforming growth factor, beta 1HPRD01631
NP_003109.17040NP_000651.1transforming growth factor, beta 1HPRD01821
NP_003109.16678NP_003109.1secreted protein, acidic, cysteine-rich (osteonectin)HPRD01631
NP_003109.17057NP_003237.1thrombospondin 1HPRD01631
NP_003109.17057NP_003237.1thrombospondin 1HPRD01765
NP_003109.17052NP_004604.1transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)HPRD01631
NP_003109.17052NP_004604.1transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)HPRD01825
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6678SPRC_HUMANP09486IPR002048EF_hand_Ca_bdCalcium-binding EF-hand
6678SPRC_HUMANP09486IPR001999OsteonectinOsteonectin-like
6678SPRC_HUMANP09486IPR002350Prot_inh_KazalProteinase inhibitor I1, Kazal
6678SPRC_HUMANP09486IPR011497Prot_Inh_Kazal_2Protease inhibitor, Kazal-type

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