Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6696
Official Symbol:SPP1
Other Aliases:BNSP|BSPI|ETA-1|MGC110940|OPN
See related:HGNC:11255|MIM:166490|HPRD:01325
Chromosome:4
Location:4q21-q25
Gene Description:secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0288
ORGANISM:human
Entrez Gene ID:6696
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.62
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20750CBCerebellum11.88981723785430.3218755722046
20750CTXCerebral cortex7.210071325302128.72810959815979
20750HIPHippocampal region6.40945458412179.9706597328186
20750HPFHippocampal formation7.3023822307586710.5003657341003
20750HYHypothalamus8.3537781238555912.8522267341614
20750LSXLateral septal complex7.143551111221319.98584175109863
20750MBMidbrain21.060345649719242.9309978485107
20750MYMedulla37.3557758331299100.0
20750OLFOlfactory bulb20.956829547882137.422417640686
20750PPons37.938716888427795.9027824401855
20750PALPallidum12.485232353210422.6605968475342
20750RHPRetrohippocampal region8.7251331806182911.1271698474884
20750sAMYStriatum-like amygdalar nuclei7.1176931858062710.1131134033203
20750STRStriatum5.234056472778327.00622034072876
20750STRdStriatum dorsal region4.4605644941336.62260746955872
20750STRvStriatum ventral region6.094171643257145.91224634647369
20750THThalamus11.926394462585420.8423004150391
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6696GO:0001503IEAProcessossification
6696GO:0001503TASProcessossification
6696GO:0005125ISSFunctioncytokine activity
6696GO:0005178NASFunctionintegrin binding
6696GO:0005515IEAFunctionprotein binding
6696GO:0005578TASComponentextracellular matrix (sensu Metazoa)
6696GO:0005615IEAComponentextracellular space
6696GO:0006916ISSProcessanti-apoptosis
6696GO:0007155IEAProcesscell adhesion
6696GO:0007160NASProcesscell-matrix adhesion
6696GO:0007267TASProcesscell-cell signaling
6696GO:0008083TASFunctiongrowth factor activity
6696GO:0030502NASProcessnegative regulation of bone mineralization
6696GO:0030595TASProcessimmune cell chemotaxis
6696GO:0042088TASProcessT-helper 1 type immune response
6696GO:0042102TASProcesspositive regulation of T cell proliferation
6696GO:0045637TASProcessregulation of myeloid cell differentiation
6696GO:0050930TASProcessinduction of positive chemotaxis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6696OSTP_HUMANP10451IPR002038OsteopontinOsteopontin

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.