Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6711
Official Symbol:SPTBN1
Other Aliases:SPTB2
See related:HGNC:11275|MIM:182790|HPRD:01683
Chromosome:2
Location:2p21
Gene Description:spectrin, beta, non-erythrocytic 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0077
ORGANISM:human
Entrez Gene ID:6711
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.17 :: -0.38 :: -0.56 :: -0.11 :: -0.71 :: -0.30 :: -0.23 :: -0.26 :: -0.43 :: -0.61
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20742CBCerebellum37.091964721679748.3003273010254
20742CTXCerebral cortex90.376571655273464.1671676635742
20742HIPHippocampal region72.7887573242188100.0
20742HPFHippocampal formation78.264564514160294.8156585693359
20742HYHypothalamus23.673772811889617.1083126068115
20742LSXLateral septal complex47.926818847656230.9481811523438
20742MBMidbrain33.245227813720725.7194862365723
20742MYMedulla29.421894073486325.7190227508545
20742OLFOlfactory bulb74.884201049804762.648811340332
20742PPons29.259849548339824.3195514678955
20742PALPallidum29.05365371704122.358980178833
20742RHPRetrohippocampal region87.470283508300874.027702331543
20742sAMYStriatum-like amygdalar nuclei61.313724517822342.2486839294434
20742STRStriatum90.159202575683664.9314727783203
20742STRdStriatum dorsal region95.318634033203169.555908203125
20742STRvStriatum ventral region87.407058715820361.1462898254395
20742THThalamus75.981231689453159.7286033630371
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6711GO:0003779IEAFunctionactin binding
6711GO:0003779TASFunctionactin binding
6711GO:0005200TASFunctionstructural constituent of cytoskeleton
6711GO:0005516IEAFunctioncalmodulin binding
6711GO:0005856IEAComponentcytoskeleton
6711GO:0008091TASComponentspectrin
6711GO:0016020IEAComponentmembrane
6711GO:0051016IEAProcessbarbed-end actin filament capping
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-23136AAC79806.1Homo sapiens putative lung tumor suppressor (DAL1) mRNA, complete cds.BIND217732
-10121NP_005727.1ARP1 actin-related protein 1 homolog A, centractin alphaHPRD05507
NP_003119.110121-Actin related protein 1AHPRD01683
NP_003119.111035NP_006862.2receptor-interacting serine-threonine kinase 3HPRD01683
NP_003119.19641NP_054721.1IKK-related kinase epsilonHPRD01683
NP_003119.1131034NP_570720.1copine IVHPRD05017
NP_003119.1131034NP_570720.1copine IVHPRD01683
NP_003119.18904NP_690902.1copine IHPRD05014
NP_003119.18904NP_690902.1copine IHPRD01683
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6711IPR001589Actnin_actin_bdActin-binding, actinin-type
6711IPR001715Calponin_act_bdCalponin-like actin-binding
6711IPR002017SpectrinSpectrin repeat
6711SPTB2_HUMANQ01082IPR001589Actnin_actin_bdActin-binding, actinin-type
6711SPTB2_HUMANQ01082IPR001715Calponin_act_bdCalponin-like actin-binding
6711SPTB2_HUMANQ01082IPR001849PHPleckstrin-like
6711SPTB2_HUMANQ01082IPR002017SpectrinSpectrin repeat
6711SPTB2_HUMANQ01082IPR001605Spectrin_PHSpectrin/pleckstrin-like

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