Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6712
Official Symbol:SPTBN2
Other Aliases:SCA5
See related:HGNC:11276|MIM:604985|HPRD:05404
Chromosome:11
Location:11q13
Gene Description:spectrin, beta, non-erythrocytic 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0212
ORGANISM:human
Entrez Gene ID:6712
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:20743
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0841
ORGANISM:human
Entrez Gene ID:6712
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.4 :: 1.5
KARG Evidence 3
KARG ID:QTL0248
ORGANISM:human
Entrez Gene ID:6712
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
KARG Evidence 4
KARG ID:QTL0248
Trait:METH responses for body temperature
Peak:0
Peak Marker:Gnblps1
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:8987796
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6712GO:0003779TASFunctionactin binding
6712GO:0005200TASFunctionstructural constituent of cytoskeleton
6712GO:0005856IEAComponentcytoskeleton
6712GO:0008091IEPComponentspectrin
6712GO:0016020IEAComponentmembrane
6712GO:0016192IDAProcessvesicle-mediated transport
6712GO:0051016IEAProcessbarbed-end actin filament capping
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_008877.1--Alpha-spectrinHPRD05404
NP_008877.1--DCTN1HPRD05404
NP_008877.1--F-actinHPRD05404
NP_008877.110121NP_005727.1ARP1 actin-related protein 1 homolog A, centractin alphaHPRD05404
NP_008877.110121NP_005727.1ARP1 actin-related protein 1 homolog A, centractin alphaHPRD05507
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6712SPTN2_HUMANO15020IPR001589Actnin_actin_bdActin-binding, actinin-type
6712SPTN2_HUMANO15020IPR001715Calponin_act_bdCalponin-like actin-binding
6712SPTN2_HUMANO15020IPR001849PHPleckstrin-like
6712SPTN2_HUMANO15020IPR002017SpectrinSpectrin repeat
6712SPTN2_HUMANO15020IPR001605Spectrin_PHSpectrin/pleckstrin-like

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