Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6748
Official Symbol:SSR4
Other Aliases:TRAPD
See related:HGNC:11326|MIM:300090|HPRD:02101
Chromosome:X
Location:Xq28
Gene Description:signal sequence receptor, delta (translocon-associated protein delta)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0160
ORGANISM:human
Entrez Gene ID:6748
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.00 :: 1.07 :: -0.25 :: -0.35 :: -1.41 :: -1.71 :: -1.26
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20832CBCerebellum34.826251983642649.0899505615234
20832CTXCerebral cortex86.046005249023470.4527587890625
20832HIPHippocampal region44.007564544677756.8050003051758
20832HPFHippocampal formation56.61089706420960.5026245117188
20832HYHypothalamus58.497402191162155.9509468078613
20832LSXLateral septal complex40.565643310546927.0481071472168
20832MBMidbrain40.95697402954138.8994140625
20832MYMedulla41.29351425170946.9017944335938
20832OLFOlfactory bulb69.749931335449261.9441795349121
20832PPons39.052158355712943.4087104797363
20832PALPallidum49.656227111816446.7813262939453
20832RHPRetrohippocampal region74.808418273925864.3564682006836
20832sAMYStriatum-like amygdalar nuclei71.147933959960955.9812355041504
20832STRStriatum55.630970001220742.7838478088379
20832STRdStriatum dorsal region53.904769897460941.716552734375
20832STRvStriatum ventral region56.671752929687542.2090873718262
20832THThalamus52.881340026855547.0410804748535
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6748GO:0005509NASFunctioncalcium ion binding
6748GO:0005783IEAComponentendoplasmic reticulum
6748GO:0005784NASComponenttranslocon complex
6748GO:0006886NASProcessintracellular protein transport
6748GO:0016020IEAComponentmembrane
6748GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-23072NP_055867.2NEDD4-like ubiquitin-protein ligase 1HPRD11385
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6748SSRD_HUMANP51571IPR008855TRAP-deltaTranslocon-associated

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