Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6751
Official Symbol:SSTR1
Other Aliases:SRIF-2
See related:HGNC:11330|MIM:182451|HPRD:01673
Chromosome:14
Location:14q13
Gene Description:somatostatin receptor 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:QTL0192
ORGANISM:human
Entrez Gene ID:6751
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20605CBCerebellum1.607891082763672.92369937896729
20605CTXCerebral cortex2.482117652893072.45820736885071
20605HIPHippocampal region3.018779516220093.33785510063171
20605HPFHippocampal formation4.84018373489384.74813985824585
20605HYHypothalamus1.139839053153990.986761868000031
20605LSXLateral septal complex0.4636473953723910.648376643657684
20605MBMidbrain1.512204289436342.01516437530518
20605MYMedulla0.7142286896705630.727552652359009
20605OLFOlfactory bulb3.739083051681523.39911222457886
20605PPons1.801789402961732.43855500221252
20605PALPallidum3.40859103202824.89241123199463
20605RHPRetrohippocampal region7.632541656494146.44501781463623
20605sAMYStriatum-like amygdalar nuclei2.435720205307012.49169397354126
20605STRStriatum0.851677834987640.959485054016113
20605STRdStriatum dorsal region0.6385600566864010.768750786781311
20605STRvStriatum ventral region1.085003733634951.03341841697693
20605THThalamus1.50952720642091.94212341308594
KARG Evidence 2
KARG ID:QTL0192
Trait:cocaine induced activation
Peak:23
Peak Marker:D12Xrf564
Parents:AXB/BXA (A = A/J, B = C57BL/6J) recombinant inbred
Evidence ID:11337941
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6751GO:0001584IEAFunctionrhodopsin-like receptor activity
6751GO:0004872IEAFunctionreceptor activity
6751GO:0004994IDAFunctionsomatostatin receptor activity
6751GO:0005886TASComponentplasma membrane
6751GO:0005887TASComponentintegral to plasma membrane
6751GO:0007187TASProcessG-protein signaling, coupled to cyclic nucleotide second messenger
6751GO:0007267TASProcesscell-cell signaling
6751GO:0007584TASProcessresponse to nutrient
6751GO:0007586TASProcessdigestion
6751GO:0008285TASProcessnegative regulation of cell proliferation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6755NP_001044.1somatostatin receptor 5HPRD01677
NP_001040.16755-Somatostatin receptor 5HPRD01673
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6751SSR1_HUMANP30872IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
6751SSR1_HUMANP30872IPR004047MCH1_rcptMelanin-concentrating hormone 1 receptor
6751SSR1_HUMANP30872IPR008361MCH_rcptMelanin-concentrating hormone receptor
6751SSR1_HUMANP30872IPR009150Neuropept_W_rcptNeuropeptide W receptor
6751SSR1_HUMANP30872IPR000611NPY_rcptNeuropeptide Y receptor
6751SSR1_HUMANP30872IPR001418Opioid_rcptOpioid receptor
6751SSR1_HUMANP30872IPR002286P2_purnocptorP2 purinoceptor
6751SSR1_HUMANP30872IPR000586Somatstn_rcptSomatostatin receptor
6751SSR1_HUMANP30872IPR001116Somatstn_rcpt_1Somatostatin receptor, type 1
6751SSR1_HUMANP30872IPR001512Somatstn_rcpt_4Somatostatin receptor, type 4

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