Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6752
Official Symbol:SSTR2
Other Aliases:-
See related:HGNC:11331|MIM:182452|HPRD:01674
Chromosome:17
Location:17q24
Gene Description:somatostatin receptor 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0458
ORGANISM:human
Entrez Gene ID:6752
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:54305
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20606CBCerebellum1.921994924545293.09362697601318
20606CTXCerebral cortex9.246117591857919.82164287567139
20606HIPHippocampal region3.166182279586793.81011843681335
20606HPFHippocampal formation3.528158664703373.86919236183167
20606HYHypothalamus0.5200254917144780.590265572071075
20606LSXLateral septal complex1.162639379501340.920129835605621
20606MBMidbrain0.7113519906997680.935747146606445
20606MYMedulla0.9609487056732181.22181355953217
20606OLFOlfactory bulb2.819165468215943.06502914428711
20606PPons3.510066986083985.11316442489624
20606PALPallidum1.06859099864961.56485390663147
20606RHPRetrohippocampal region4.260320663452154.09131908416748
20606sAMYStriatum-like amygdalar nuclei1.780762195587161.76868581771851
20606STRStriatum2.950971603393553.51447510719299
20606STRdStriatum dorsal region4.139199733734135.11769342422485
20606STRvStriatum ventral region0.495070755481720.762566983699799
20606THThalamus1.498404979705811.89221346378326
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6752GO:0001584IEAFunctionrhodopsin-like receptor activity
6752GO:0004872IEAFunctionreceptor activity
6752GO:0004994TASFunctionsomatostatin receptor activity
6752GO:0005515IPIFunctionprotein binding
6752GO:0005886TASComponentplasma membrane
6752GO:0005887TASComponentintegral to plasma membrane
6752GO:0007165IEAProcesssignal transduction
6752GO:0007187TASProcessG-protein signaling, coupled to cyclic nucleotide second messenger
6752GO:0007267TASProcesscell-cell signaling
6752GO:0007584TASProcessresponse to nutrient
6752GO:0007586TASProcessdigestion
6752GO:0008285TASProcessnegative regulation of cell proliferation
6752GO:0030165IPIFunctionPDZ domain binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-22941NP_036441.1SH3 and multiple ankyrin repeat domains 2 isoform 1HPRD04479
-50944NP_057232.1SH3 and multiple ankyrin repeat domains 1HPRD05413
NP_001041.122941-SH3 and multiple ankyrin repeat domains 2HPRD01674
NP_001041.150944-SH3 and multiple ankyrin repeat domains 1HPRD01674
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6752SSR2_HUMANP30874IPR000826Frt_met_rcptFormyl/methionyl peptide receptor
6752SSR2_HUMANP30874IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
6752SSR2_HUMANP30874IPR008361MCH_rcptMelanin-concentrating hormone receptor
6752SSR2_HUMANP30874IPR009150Neuropept_W_rcptNeuropeptide W receptor
6752SSR2_HUMANP30874IPR000611NPY_rcptNeuropeptide Y receptor
6752SSR2_HUMANP30874IPR001418Opioid_rcptOpioid receptor
6752SSR2_HUMANP30874IPR002286P2_purnocptorP2 purinoceptor
6752SSR2_HUMANP30874IPR000586Somatstn_rcptSomatostatin receptor
6752SSR2_HUMANP30874IPR001184Somatstn_rcpt_5Somatostatin receptor, type 5
6752SSR2_HUMANP30874IPR002074Somatstn_rcpt_2Somatostatin receptor, type 2

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