Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6804
Official Symbol:STX1A
Other Aliases:HPC-1|STX1|p35-1
See related:HGNC:11433|MIM:186590|HPRD:01721
Chromosome:7
Location:7q11.23
Gene Description:syntaxin 1A (brain)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0257
ORGANISM:human
Entrez Gene ID:6804
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:20907
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20907CBCerebellum14.44342374801649.65898847579956
20907CTXCerebral cortex100.0100.0
20907HIPHippocampal region65.011867523193464.4305324554443
20907HPFHippocampal formation96.846496582031292.8609352111816
20907HYHypothalamus74.670761108398438.165376663208
20907LSXLateral septal complex23.385194778442412.2504043579102
20907MBMidbrain52.796503067016629.7519721984863
20907MYMedulla36.331871032714823.2904472351074
20907OLFOlfactory bulb100.0100.0
20907PPons45.243728637695327.7170276641846
20907PALPallidum39.507516860961923.9612636566162
20907RHPRetrohippocampal region100.0100.0
20907sAMYStriatum-like amygdalar nuclei71.776130676269553.6459331512451
20907STRStriatum31.810193061828620.1385345458984
20907STRdStriatum dorsal region18.694509506225613.582724571228
20907STRvStriatum ventral region63.230787277221726.7829351425171
20907THThalamus52.869180679321333.0149421691895
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6804GO:0005515IPIFunctionprotein binding
6804GO:0006836IEAProcessneurotransmitter transport
6804GO:0006886IEAProcessintracellular protein transport
6804GO:0006887NRProcessexocytosis
6804GO:0008565IEAFunctionprotein transporter activity
6804GO:0016020IEAComponentmembrane
6804GO:0016021IEAComponentintegral to membrane
6804GO:0050796TASProcessregulation of insulin secretion
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-29091AAM46624.1Homo sapiens amisyn mRNA, complete cds.HPRD06410
-6812NP_003156.1syntaxin binding protein 1 isoform aHPRD04235
-8673NP_003752.2vesicle-associated membrane protein 8HPRD04415
-10497NP_006368.1UNC13 (C. elegans)-likeHPRD05785
-10815NP_006642.1complexin 1HPRD09233
-6813NP_008880.1syntaxin binding protein 2HPRD03423
-6860NP_065834.1synaptotagmin IVHPRD02519
-94121NP_542775.1synaptotagmin-like 4 (granuphilin-a)HPRD06735
-134957NP_640337.2tomosynHPRD06845
NP_004594.1--alpha-SNAPHPRD01721
NP_004594.1--Munc18aHPRD01721
NP_004594.1--VAMP2HPRD01721
NP_004594.1--Munc18bHPRD01721
NP_004594.1--GAT1HPRD01721
NP_004594.1--ENaC proteinHPRD01721
NP_004594.1--SyntaphilinHPRD01721
NP_004594.1--VAMP1HPRD01721
NP_004594.1--Complexin 2HPRD01721
NP_004594.1--TaxilinHPRD01721
NP_004594.1--H+ ATPaseHPRD01721
NP_004594.1---BIND259563
NP_004594.110815-Complexin 1HPRD01721
NP_004594.16813-Syntaxin binding protein 2HPRD01721
NP_004594.110497-MUNC13HPRD01721
NP_004594.16812-Syntaxin binding protein 1HPRD01721
NP_004594.1134957-TomosynHPRD01721
NP_004594.16860-Synaptotagmin 4HPRD01721
NP_004594.18673-Vesicle associated membrane protein 8HPRD01721
NP_004594.194121-Synaptotagmin like 4HPRD01721
NP_004594.129091AAM46624.1Homo sapiens amisyn mRNA, complete cds.HPRD01721
NP_004594.18773NP_003816.2synaptosomal-associated protein 23 isoform SNAP23AHPRD03962
NP_004594.18773NP_003816.2synaptosomal-associated protein 23 isoform SNAP23AHPRD01721
NP_004594.19066NP_004191.2synaptotagmin VIIHPRD11965
NP_004594.19342NP_004773.1synaptosomal-associated protein 29HPRD11968
NP_004594.19482NP_004844.1syntaxin 8HPRD05012
NP_004594.19482NP_004844.1syntaxin 8HPRD01721
NP_004594.16845NP_005629.1synaptobrevin-like 1HPRD02084
NP_004594.16845NP_005629.1synaptobrevin-like 1HPRD01721
NP_004594.16857NP_005630.1synaptotagmin IHPRD01710
NP_004594.16857NP_005630.1synaptotagmin IHPRD01721
NP_004594.157617NP_065908.1vacuolar protein sorting 18BIND258898
NP_004594.155823NP_068375.3vacuolar protein sorting 11 (yeast homolog)BIND258899
NP_004594.1167838NP_694967.2muscle-derived protein 77HPRD10793
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6804STX1A_HUMANQ16623IPR001399Orbi_VP6VP6 blue-tongue virus inner capsid protein
6804STX1A_HUMANQ16623IPR006012SyntaxinSyntaxin/epimorphin family
6804STX1A_HUMANQ16623IPR006011Syntaxin_NSyntaxin, N-terminal
6804STX1A_HUMANQ16623IPR000727T_SNARETarget SNARE coiled-coil region

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