Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6813
Official Symbol:STXBP2
Other Aliases:Hunc18b|MUNC18-2|UNC18-2|UNC18B|pp10122
See related:HGNC:11445|MIM:601717|HPRD:03423
Chromosome:19
Location:19p13.3-p13.2
Gene Description:syntaxin binding protein 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0361
ORGANISM:human
Entrez Gene ID:6813
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.5 :: -1.3 :: -1.4 :: -1.5 :: -1.4 :: -1.5
KARG Evidence 2
KARG ID:EVIM0429
ORGANISM:human
Entrez Gene ID:6813
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.5 :: -1.4 :: -1.2 :: -1.3 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20911CBCerebellum61.775741577148478.3186798095703
20911CTXCerebral cortex100.0100.0
20911HIPHippocampal region86.2136268615723100.0
20911HPFHippocampal formation100.0100.0
20911HYHypothalamus97.390411376953174.9657764434814
20911LSXLateral septal complex100.095.0648078918457
20911MBMidbrain64.590454101562551.9727115631104
20911MYMedulla71.486976623535268.412166595459
20911OLFOlfactory bulb100.0100.0
20911PPons78.611358642578168.9837970733643
20911PALPallidum98.632686614990282.6888847351074
20911RHPRetrohippocampal region100.0100.0
20911sAMYStriatum-like amygdalar nuclei100.0100.0
20911STRStriatum100.0100.0
20911STRdStriatum dorsal region100.0100.0
20911STRvStriatum ventral region100.0100.0
20911THThalamus98.813724517822379.5044288635254
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6813GO:0006886NASProcessintracellular protein transport
6813GO:0006904IEAProcessvesicle docking during exocytosis
6813GO:0008372NDComponentcellular component unknown
6813GO:0016192IEAProcessvesicle-mediated transport
6813GO:0030347NASFunctionsyntaxin-2 binding
6813GO:0030348NASFunctionsyntaxin-3 binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8773NP_003816.2synaptosomal-associated protein 23 isoform SNAP23AHPRD03962
-6844NP_055047.1vesicle-associated membrane protein 2 (synaptobrevin 2)HPRD01717
NP_008880.1--Syntaxin 2HPRD03423
NP_008880.1--Syntaxin 3HPRD03423
NP_008880.16844-Synaptobrevin 2HPRD03423
NP_008880.18773-SNAP23HPRD03423
NP_008880.16814NP_009200.1syntaxin binding protein 3HPRD10517
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6813STXB2_HUMANQ15833IPR001619Sec1-likeSec1-like protein

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