Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6854
Official Symbol:SYN2
Other Aliases:SYNII|SYNIIa|SYNIIb
See related:HGNC:11495|MIM:600755|HPRD:02857
Chromosome:3
Location:3p25
Gene Description:synapsin II
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0414
ORGANISM:human
Entrez Gene ID:6854
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1 :: 1.1 :: 1.3 :: -1.1 :: -1.5 :: -2
KARG Evidence 2
KARG ID:EVIM0482
ORGANISM:human
Entrez Gene ID:6854
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.6 :: -1.5 :: -1.6 :: -1.3 :: 1.1
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20965CBCerebellum60.540220260620191.9914741516113
20965CTXCerebral cortex100.0100.0
20965HIPHippocampal region100.0100.0
20965HPFHippocampal formation100.0100.0
20965HYHypothalamus100.0100.0
20965LSXLateral septal complex88.102882385253989.5297241210938
20965MBMidbrain94.3091621398926100.0
20965MYMedulla74.4724159240723100.0
20965OLFOlfactory bulb100.0100.0
20965PPons79.8743934631348100.0
20965PALPallidum87.3691864013672100.0
20965RHPRetrohippocampal region100.0100.0
20965sAMYStriatum-like amygdalar nuclei100.0100.0
20965STRStriatum97.5557556152344100.0
20965STRdStriatum dorsal region78.694255828857473.8924865722656
20965STRvStriatum ventral region100.0100.0
20965THThalamus76.394729614257899.6653671264648
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6854GO:0007268TASProcesssynaptic transmission
6854GO:0007269IEAProcessneurotransmitter secretion
6854GO:0008021IEAComponentsynaptic vesicle
6854GO:0045202IEAComponentsynapse
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8224NP_003481.2synapsin III isoform IIIaHPRD04083
-9722NP_055512.1nitric oxide synthase 1 (neuronal) adaptor proteinHPRD12023
NP_598328.18224-Synapsin IIIHPRD02857
NP_598328.16854NP_598328.1synapsin II isoform IIaHPRD02857
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6854SYN2_HUMANQ92777IPR002979Anion_exhngr3Anion exchanger, isoform 3
6854SYN2_HUMANQ92777IPR000694PRO_richProline-rich region
6854SYN2_HUMANQ92777IPR001359SynapsinSynapsin

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