Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6857
Official Symbol:SYT1
Other Aliases:DKFZp781D2042|P65|SVP65|SYT
See related:HGNC:11509|MIM:185605|HPRD:01710
Chromosome:12
Location:12cen-q21
Gene Description:synaptotagmin I
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0353
ORGANISM:human
Entrez Gene ID:6857
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.84
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20979CBCerebellum100.0100.0
20979CTXCerebral cortex100.0100.0
20979HIPHippocampal region100.0100.0
20979HPFHippocampal formation100.0100.0
20979HYHypothalamus100.0100.0
20979LSXLateral septal complex100.0100.0
20979MBMidbrain100.0100.0
20979MYMedulla100.0100.0
20979OLFOlfactory bulb100.0100.0
20979PPons100.0100.0
20979PALPallidum100.0100.0
20979RHPRetrohippocampal region100.0100.0
20979sAMYStriatum-like amygdalar nuclei100.0100.0
20979STRStriatum100.0100.0
20979STRdStriatum dorsal region100.0100.0
20979STRvStriatum ventral region100.0100.0
20979THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6857GO:0005215IEAFunctiontransporter activity
6857GO:0005509IEAFunctioncalcium ion binding
6857GO:0005513TASProcessdetection of calcium ion
6857GO:0005515IPIFunctionprotein binding
6857GO:0005515TASFunctionprotein binding
6857GO:0005543TASFunctionphospholipid binding
6857GO:0005545TASFunctionphosphatidylinositol binding
6857GO:0006810IEAProcesstransport
6857GO:0007268TASProcesssynaptic transmission
6857GO:0007269TASProcessneurotransmitter secretion
6857GO:0008021TASComponentsynaptic vesicle
6857GO:0016020IEAComponentmembrane
6857GO:0016021IEAComponentintegral to membrane
6857GO:0017075TASFunctionsyntaxin-1 binding
6857GO:0017157TASProcessregulation of exocytosis
6857GO:0045202IEAComponentsynapse
6857GO:0050750IDAFunctionlow-density lipoprotein receptor binding
6857GO:0051260TASProcessprotein homooligomerization
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9378NP_004792.1neurexin 1 isoform alpha precursorHPRD11858
-10492NP_006363.3synaptotagmin binding, cytoplasmic RNA interacting proteinHPRD06734
-10815NP_006642.1complexin 1HPRD09233
-9899NP_055663.1synaptic vesicle protein 2B homologHPRD11765
-6860NP_065834.1synaptotagmin IVHPRD02519
NP_005630.1--AP-2HPRD01710
NP_005630.1--CalmodulinHPRD01710
NP_005630.1--Neurexin 1HPRD01710
NP_005630.1--Stonin 2HPRD01710
NP_005630.110815-Complexin 1HPRD01710
NP_005630.16860-Synaptotagmin 4HPRD01710
NP_005630.110492-NS1 associated protein 1HPRD01710
NP_005630.123390NP_056151.1huntingtin interacting protein 14BIND195709
NP_005630.185439NP_149095.2stonin 2HPRD10531
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6857SYT1_HUMANP21579IPR002149Alatroxin_rcptA-latrotoxin receptor interaction
6857SYT1_HUMANP21579IPR000008C2C2
6857SYT1_HUMANP21579IPR013583PRT_C_plnPhosphoribosyltransferase C-terminal, plant
6857SYT1_HUMANP21579IPR001565SynaptotagminSynaptotagmin

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.