Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6863
Official Symbol:TAC1
Other Aliases:Hs.2563|NK2|NKNA|TAC2
See related:HGNC:11517|MIM:162320|HPRD:08876
Chromosome:7
Location:7q21-q22
Gene Description:tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0113
ORGANISM:human
Entrez Gene ID:6863
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:21333
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0533
ORGANISM:human
Entrez Gene ID:6863
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24806
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
21333CBCerebellum3.386883378028874.43445992469788
21333CTXCerebral cortex8.8641231060028111.7636461257935
21333HIPHippocampal region3.658851265907297.21354198455811
21333HPFHippocampal formation7.5547869205474911.9370732307434
21333HYHypothalamus23.28900527954142.91455078125
21333LSXLateral septal complex17.408472537994424.2983484268188
21333MBMidbrain15.99694061279324.4098739624023
21333MYMedulla10.312435626983616.7679615020752
21333OLFOlfactory bulb10.582295417785615.5488739013672
21333PPons6.432573080062879.62039613723755
21333PALPallidum14.741507053375224.1055250167847
21333RHPRetrohippocampal region13.669270515441917.5109195709229
21333sAMYStriatum-like amygdalar nuclei30.607110977172951.9820213317871
21333STRStriatum89.5926551818848100.0
21333STRdStriatum dorsal region91.8373146057129100.0
21333STRvStriatum ventral region100.0100.0
21333THThalamus3.437127351760865.81607484817505
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6863GO:0005102TASFunctionreceptor binding
6863GO:0005184NRFunctionneuropeptide hormone activity
6863GO:0005615TASComponentextracellular space
6863GO:0007217IEAProcesstachykinin signaling pathway
6863GO:0007218IEAProcessneuropeptide signaling pathway
6863GO:0007267TASProcesscell-cell signaling
6863GO:0007268IEAProcesssynaptic transmission
6863GO:0007320TASProcessinsemination
6863GO:0009582TASProcessdetection of abiotic stimulus
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6865NP_001048.1tachykinin receptor 2HPRD01207
-6870NP_001050.1tachykinin receptor 3HPRD01209
NP_003173.16865-Tachykinin receptor 2HPRD08876
NP_003173.16870-Tachykinin receptor 3HPRD08876
NP_003173.16869NP_001049.1tachykinin receptor 1 isoform longHPRD08876
NP_003173.16869NP_001049.1tachykinin receptor 1 isoform longHPRD01208
NP_003173.16866NP_037383.1tachykinin 3 isoform 2HPRD08876
NP_003173.16866NP_037383.1tachykinin 3 isoform 2HPRD08877
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6863IPR008216ProtachykininProtachykinin
6863IPR002040Tachy_NeurokininTachykinin/Neurokinin
6863IPR013055Tachy_Neuro_lkeTachykinin/Neurokinin like
6863TKN1_HUMANP20366IPR008216ProtachykininProtachykinin
6863TKN1_HUMANP20366IPR002040Tachy_NeurokininTachykinin/Neurokinin
6863TKN1_HUMANP20366IPR013055Tachy_Neuro_lkeTachykinin/Neurokinin like

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